Results 61 to 70 of about 805,763 (399)
Evaluating the role of aldosterone synthesis on adrenal cell fate
Frontiers in EndocrinologyHypertension affects one-third of the adult population worldwide, with primary aldosteronism (PA) accounting for at least 5-10% of these cases. The aldosterone synthase enzyme (CYP11B2) plays a pivotal role in PA manifestation, as increased expression of
Amnani Aminuddin +5 more
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Double NF1 inactivation affects adrenocortical function in NF1Prx1 mice and a human patient.
PLoS ONE, 2015 BackgroundNeurofibromatosis type I (NF1, MIM#162200) is a relatively frequent genetic condition, which predisposes to tumor formation. Apart from tumors, individuals with NF1 often exhibit endocrine abnormalities such as precocious puberty (2,5-5% of NF1
Karolina Kobus +14 more
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Acta Pediátrica de México, 2014 Background: Adrenal cortex tumors (ACT) are extremely rare in children and adolescents. Only 0.2% of all the new cases of cancer diagnosed in the United Stated and Europe are adrenal cortex tumors.
Paola de Baro-Álvarez +4 more
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Isolation and in vitro cultivation of adrenal cells from mice
STAR Protocols, 2021 Summary: The adrenal gland consists of two tissues, cortex and medulla, united under one capsule. Adrenal stem/progenitor cells play a key role in development and homeostasis.
Linda Friedrich +5 more
doaj +1 more source
Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. [PDF]
, 1981 Two different monoclonal antibodies, characterized initially as binding synaptic terminal regions of rat brain, bind a 65,000-dalton protein, which is exposed on the outer surface of brain synaptic vesicles. Immunocytochemical experiments at the electron
Matthew, WD, Reichardt, LF, Tsavaler, L
core +2 more sources
The Innervation of the Adrenal Cortex
Archivum histologicum japonicum, 1967 1. The distribution and termination of nerve fibers in the mammalian and avian adrenal cortices was histologically investigated in sections treated with a modification of the Bielschowsky silver-impregnation method.2. Juxtacapsular ganglia were found in the monkey and dog.
T, Shioda, S, Nishida
openaire +3 more sources
Advanced Science, EarlyView.We developed a smart MRI nanoprobe targeting BACE1 and Aβ plaques. It crosses the blood‐brain barrier. Upon encountering BACE1, the probe is cleaved, enabling T1WI imaging detection. Subsequent reaction with ONOO− induces probe aggregation, enhancing magnetic susceptibility for sensitive SWI imaging of Aβ plaques.
Minghua Li +13 more
wiley +1 more source
Latent Adrenal Insufficiency: From Concept to Diagnosis
Frontiers in Endocrinology, 2021 Primary adrenal insufficiency (PAI) is a rare disease and potentially fatal if unrecognized. It is characterized by destruction of the adrenal cortex, most frequently of autoimmune origin, resulting in glucocorticoid, mineralocorticoid, and adrenal ...
Nada Younes +2 more
doaj +1 more source
Familial Micronodular Adrenocortical Disease, Cushing Syndrome, and Mutations of the Gene Encoding Phosphodiesterase 11A4 ( PDE11A) [PDF]
, 2014 We present the pathologic findings in the adrenal glands of 4 patients, aged 10 to 38 years, with Cushing syndrome and germline inactivating mutations of the gene PDE11A4 that encodes phosphodiesterase11A4. The gene is expressed in the adrenal cortex and
Bertherat, J. +3 more
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Advanced Science, EarlyView.Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
wiley +1 more source