Results 81 to 90 of about 79,543 (252)

FOS and JUN regulate oxidative stress and steroidogenesis in human aldosterone-producing adenomas

Redox Biology
Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism (PA). While oxidative stress and steroidogenesis are intricately linked in adrenal disorders, their interplay and mechanistic basis in APA pathogenesis remain to be fully ...
Jia Wei, Eleonora Duregon, Mauro G. Papotti, Thomas Knösel, Martin Bidlingmaier, Silviu Sbiera, Martin Reincke, Tracy Ann Williams   +7 more
doaj   +1 more source

ACTH Stimulation Testing Is Often Unnecessary After Appropriate Patient Preparation Prior to Screening Cortisol Measurement

Clinical Endocrinology, EarlyView.
ABSTRACT Context Screening morning serum cortisol is used to select patients for ACTH stimulation testing to diagnose adrenal insufficiency (AI) but may be affected by pre‐analytical factors. Careful consideration to discontinue confounding medications beforehand may preclude the need for subsequent stimulation testing.
Christopher J. Symonds, Alexander A. Leung, Gregory A. Kline   +2 more
wiley   +1 more source

Vascular endothelial growth factor and endocan expression in adrenal cortical tumors and their relationship with histopathological prognostic parameters

Endocrine Journal
The aim of this study was to determine the tissue expressions of vascular endothelial growth factor (VEGF) and endocan in adrenal cortical tumors and the factors associated with them.
Melia Karaköse, Mustafa Can, Muhammet Kocabaş, Hacı Hasan Esen, Mustafa Kulaksızoğlu, Feridun Karakurt   +5 more
doaj   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Morphological and Transcriptomic Analyses of the Adrenal Gland in Acomys cahirinus: A Novel Model for Murine Adrenal Physiology

Cells
This study investigates the adrenal gland structure and gene expression in Acomys cahirinus compared to Mus musculus, aiming to assess its relevance for human adrenal disease modeling.
Alina Bilyalova, Airat Bilyalov, Olga Kozlova, Nikita Filatov, Daria Filimoshina, Guzel Gazizova, Ruslan Deviatiiarov, Angelina Titova, Andrey Bydanov, Yana Mukhamedshina, Elena Shagimardanova, Andrey Kiyasov, Dmitry Tychinin, Mary Woroncow, Oleg Gusev   +14 more
doaj   +1 more source

Age-related Changes in the Adrenal Cortex: Insights and Implications. [PDF]

J Endocr Soc, 2023
Warde KM, Smith LJ, Basham KJ.
europepmc   +1 more source

An experimental approach to assess the combined effects of multiple stressors on a large vertebrate species

Conservation Biology, EarlyView.
Abstract The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure.
Enrico Pirotta, Catriona M. Harris, Lori H. Schwacke, Len Thomas, Jason B. Allen, Aaron A. Barleycorn, Marco Casoli, Jonathan Crossman, Laura Aichinger Dias, Laura Engleby, Erin LaBrecque, Jenny A. Litz, Katherine A. McHugh, Patrick J. O. Miller, Michael J. Moore, Theoni Photopoulou, Brian M. Quigley, Cynthia R. Smith, Brandon L. Southall, Todd R. Speakman, Ryan Takeshita, Christina N. Toms, Randall S. Wells, Eric S. Zolman, Peter L. Tyack   +24 more
wiley   +1 more source

Outbreak of poisoning by sodium hydrogen methylarsonate (MSMA)—an arsenic‐based herbicide—in horses in Brazil

Equine Veterinary Journal, EarlyView.
Abstract Background Arsenic poisoning in horses is rarely reported in the literature. However, arsenic compounds can be present in rodenticides, pesticides, and herbicides, representing a potential source of accidental exposure for horses. Objective To describe the epidemiological, clinical, and laboratory findings from a herd of 31 horses exposed to ...
Gabriella Faria Pereira, Maria Clara Hornich Blimbliem, Anna Laura Previato Rosa Machado, Junara Bianca Rosa Abdala, Geison Morel Nogueira, Hugo Shisei Toma, Tatiane Furtado de Carvalho, Diego José Zanzarini Delfiol   +7 more
wiley   +1 more source

AAV-delivered hepato-adrenal cooperativity in steroidogenesis: Implications for gene therapy for congenital adrenal hyperplasia

Molecular Therapy: Methods & Clinical Development
Despite the availability of life-saving corticosteroids for 70 years, treatment for adrenal insufficiency is not able to recapitulate physiological diurnal cortisol secretion and results in numerous complications.
Lara E. Graves, Eva B. van Dijk, Erhua Zhu, Sundar Koyyalamudi, Tiffany Wotton, Dinah Sung, Shubha Srinivasan, Samantha L. Ginn, Ian E. Alexander   +8 more
doaj   +1 more source

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source