Results 91 to 100 of about 2,389,380 (305)

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Adrenal Artery Ablation for the Treatment of Hypercortisolism Based on Adrenal Venous Sampling: A Potential Therapeutic Strategy

Diabetes, Metabolic Syndrome and Obesity, 2020
Qing Zhou, Xiaoli Liu, Hexuan Zhang, Zhigang Zhao, Qiang Li, Hongbo He, Zhiming Zhu, Zhencheng Yan Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Chongqing Institute of Hypertension, Daping Hospital and the ...
Zhou Q, Liu X, Zhang H, Zhao Z, Li Q, He H, Zhu Z, Yan Z   +7 more
doaj  

Addison’s disease associated to paracocidioidomycosis

Brazilian Journal of Oral Sciences, 2015
Paracoccidioidomycosis is a deep mycosis caused by the Paracoccidioides brasiliensis and it has been considered the most frequent systemic mycosis in Latin America.
Claudio Maranhão Pereira, Silmara Regina Silva, Priscila Spaziane Camargo, Andrea Mantesso, Rodrigo Calado Nunes Souza   +4 more
doaj   +1 more source

How developmental stressors affect mitochondrial respiratory function: a systematic review and meta‐analysis

Biological Reviews, EarlyView.
ABSTRACT The environmental conditions organisms experience during early development can have powerful and sustained effects on morphology, physiology, behaviour, and performance. Such developmental effects can influence reproductive success, survival, and life‐history strategies and can be transmitted across generations (i.e.
Ondi L. Crino, Christopher R. Friesen, Geoffrey E. Hill, Dalton C. Leibold, Pablo Recio, Karine Salin, Kristoffer H. Wild, Daniel W.A. Noble   +7 more
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

The Adrenal Gland: Central Relay in Health and Disease [PDF]

, 2019
Diseases of the adrenal gland are as important for the general practitioner as for the endocrine specialist. The high prevalence of some adrenal endocrinopathies, such as adrenal incidentalomas (1-2% of the population) and primary aldosteronism (6% of ...
Williams, T. A., Beuschlein, Felix, Eisenhofer, Graeme, Reisch, Nicole, Williams, Tracy A., Bornstein, Stefan, Fassnacht, Martin, Williams, Tracy Ann, Reincke, Martin   +8 more
core   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Adrenal Gland and Lung Lesions in Gulf of Mexico Common Bottlenose Dolphins (Tursiops truncatus) Found Dead following the Deepwater Horizon Oil Spill.

PLoS ONE, 2015
A northern Gulf of Mexico (GoM) cetacean unusual mortality event (UME) involving primarily bottlenose dolphins (Tursiops truncatus) in Louisiana, Mississippi, and Alabama began in February 2010 and continued into 2014.
Stephanie Venn-Watson, Kathleen M Colegrove, Jenny Litz, Michael Kinsel, Karen Terio, Jeremiah Saliki, Spencer Fire, Ruth Carmichael, Connie Chevis, Wendy Hatchett, Jonathan Pitchford, Mandy Tumlin, Cara Field, Suzanne Smith, Ruth Ewing, Deborah Fauquier, Gretchen Lovewell, Heidi Whitehead, David Rotstein, Wayne McFee, Erin Fougeres, Teri Rowles   +21 more
doaj   +1 more source

Broadband dielectric properties of adrenal gland for accurate anatomical modelling in medical applications

, 2019
Dielectric properties of biological tissue are important in safety assessment and evaluation of novel medical imaging and therapeutic devices. This paper reports frequency dependent dielectric properties of adrenal tissue, which is a potential target for
Prakash, Punit, Clausing, Daniel, Dennedy, Michael C., Shahzad, Atif, O'Halloran, Martin   +4 more
core   +1 more source

Impairment of adrenocortical function associated with increased plasma tumor necrosis factor-alpha and interleukin 6 concentrations in African trypanosomiasis [PDF]

, 1994
African sleeping sickness (SS) is a severe, potentially lethal parasitic disease. The treatments of choice are the antiparasitic agents suramin, which is adrenotoxic, and/or melarsoprol. We evaluated the functional integrity of the hypothalamic-pituitary-
Winkelmann, W., Reincke, M, Allolio, B., Siekmann, L., Heppner, C, Arlt, W, Petzke, F, Arlt, W., Mbulamberi, D, Vollmer, D, Chrousos, G. P., Allolio, B, Siekmann, L, Vollmer, D., Heppner, C., Mbulamberi, D., Winkelmann, W, Reincke, Martin, Petzke, F., Chrousos, G P   +19 more
core   +1 more source