Results 211 to 220 of about 37,949 (281)

Pharmacological evaluation of non‐nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Traumatic brain injury (TBI) is considered to be a leading cause of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage‐associated molecular patterns, such as ATP release, recognised by P2X7 receptors.
Inés Valencia   +15 more
wiley   +1 more source

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

open access: yesBritish Journal of Pharmacology, EarlyView.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota   +4 more
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

open access: yesBritish Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages. [PDF]

open access: yesCommun Biol
Xu Y   +6 more
europepmc   +1 more source

Serum Inhibin Concentration in Dogs with Adrenal Gland Disease and in Healthy Dogs

open access: hybrid, 2013
Catharina Brömel   +7 more
openalex   +1 more source

Beyond synapses: cytoplasmic connections in brain function and evolution

open access: yesBiological Reviews, EarlyView.
ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley   +1 more source

Case Report: Bilateral adrenal hemorrhage and hemophagocytosis in the reticuloendothelial system caused by <i>Escherichia coli</i> in a young woman: an autopsy case. [PDF]

open access: yesFront Med (Lausanne)
Tanaka Y   +13 more
europepmc   +1 more source

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