Results 51 to 60 of about 2,389,380 (305)

Single‐nucleus and spatial transcriptome reveal adrenal homeostasis in normal and tumoural adrenal glands

Clinical and Translational Medicine
The human adrenal gland is a complex endocrine tissue. Studies on adrenal renewal have been limited to animal models or human foetuses. Enhancing our understanding of adult human adrenal homeostasis is crucial for gaining insights into the pathogenesis ...
Barbara Altieri, A. Kerim Secener, Somesh Sai, Cornelius Fischer, Silviu Sbiera, Panagiota Arampatzi, Stefan Kircher, Sabine Herterich, Laura‐Sophie Landwehr, Sarah N. Vitcetz, Caroline Braeuning, Martin Fassnacht, Cristina L. Ronchi, Sascha Sauer   +13 more
doaj   +1 more source

Hypertension in adrenal pathology: clinical cases

Mìžnarodnij Endokrinologìčnij Žurnal, 2022
Hyperproduction of hormones by adrenal tissues, or (less often) by their cells ectopic into other organs, naturally leads to the development of secondary hypertension, usually refractory to classical antihypertensive drugs.
P.M. Lіashuk, R.P. Lіashuk
doaj   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Traumatic rupture of adrenal pseudocyst leading to massive hemorrhage in retroperitoneum

International Brazilian Journal of Urology, 2004
We present the case of a patient who had a large pseudocyst in the right adrenal gland, which was ruptured following blunt abdominal trauma, leading to a voluminous hemorrhage in retroperitoneum. A 29-year old female patient was admitted in the emergency
Favorito Luciano A., Lott Felipe M., Cavalcante André G.   +2 more
doaj  

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Adrenal hematopoiesis in a pediatric patient with spherocytosis: A case report and literature review

Radiology Case Reports
Extramedullary hematopoiesis (EMH) is extremely rare in the adrenal glands, especially in children. Because this is an underrecognized condition, the vast majority of cases are diagnosed only after adrenalectomy.
Rawa Bapir, Ismaeel Aghaways, Sharaza Qadir Omer, Rezheen J. Rashid, Shaho F. Ahmed, Hadeel Adnan Yasseen, Hardi M. Dhahir, Honar O. Kareem, Dilan S. Hiwa, Berun A. Abdalla, Fahmi H. Kakamad   +10 more
doaj   +1 more source

Development of adrenal 3-dimensional spheroid cultures: potential for the treatment of adrenal insufficiency and neurodegenerative diseases [PDF]

Exploration of Endocrine and Metabolic Diseases
Aim: Regenerative and curative strategies would be desirable for neurodegenerative and adrenal diseases, and multipotent adrenal stem cells are considered as promising biological tools for this purpose.
Charlotte Steenblock, Stephanie Fliedner, Giatgen A. Spinas, Racheli Ofir, Patrick Kugelmeier, Barbara Ludwig, Nicole Bechmann   +6 more
doaj   +1 more source

Progressive onset of adrenal insufficiency and hypogonadism of pituitary origin caused by a complex genetic rearrangement within DAX-1 [PDF]

, 2002
DAX-1 [dosage-sensitive sex reversal, adrenal hypoplasia congenital (AHC) critical region on the X chromosome, gene 11 is a transcription factor expressed in the adrenal gland and at all levels of the gonadotrope axis.
Gaillard, R.C., Schorderet, D., Schorderet, D, Jameson, J.L., Pralong, F.P., Gaillard, RC, Fiaux, M., Achermann, JC, Salvi, R, Achermann, J.C., Gomez, F, Fiaux, M, Pralong, FP, Jameson, JL, Salvi, R., Gomez, F.   +15 more
core   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source