Results 91 to 100 of about 115,138 (364)

Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells

BioEssays, EarlyView.
Primary cilia are developmentally essential subcellular signaling compartments. However, many differentiated cells lack primary cilia, and cilia disassembly in these tissue contexts has been largely overlooked. We highlight several pathways for primary cilia loss and examine how changes in ciliation states could contribute to diverse pathologies ...
Carolyn M. Ott, Saikat Mukhopadhyay
wiley   +1 more source

Solid-pseudopapillary tumor of the pancreas: A single center experience [PDF]

, 2016
open6noAim of this study was to review the institutional experience of solid-pseudopapillary tumors of the pancreas with particular attention to the problems of preoperative diagnosis and treatment.
Alberto Fantin, Cosimo Sperti, Enrico Dalla Bona, Gioia Pozza, Michele Valmasoni, Valentina Beltrame   +5 more
core   +3 more sources

Fusion Pores as Regulators of Quantal Size and Cellular Physiology

BioEssays, EarlyView.
During regulated exocytosis, membrane fusion regulatory factors act directly on SNAREs and membrane lipids to control fusion pore dynamics. This, in turn, leads to a differential amount of cargo release (referred to in this article as “quantal size”) across various cell types, thereby triggering distinct physiological cues.
Bhavya R. Bhaskar, Shahina Mazumdar, Sruthilaya Dayanandan, Debasis Das   +3 more
wiley   +1 more source

Pediatric adrenocortical tumors: what they can tell us on adrenal development and comparison with adult adrenal tumors

Frontiers in Endocrinology, 2015
Adrenocortical tumors (ACT) in children are very rare and are most frequently diagnosed in the context of the Li-Fraumeni syndrome, a multiple cancer syndrome linked to germline mutations of the tumor suppressor gene TP53 with loss of heterozygosity in ...
Enzo eLalli, Bonald C. Figueiredo
doaj   +1 more source

GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior [PDF]

, 2017
Background: Discrimination between benign and malignant tumors is a challenging process in pediatric adrenocortical tumors. New insights in the metabolic profile of pediatric adrenocortical tumors may contribute to this distinction, predict prognosis, as
Allolio, Allolio, Allolio, Almeida, Arap, Baltazar, Baltazar, Baltazar, Baltazar, Baltazar, Baudin, Bouley, Casal, Casal, Chatterjee, Chuang, Deal, DeLacerda, Fassnacht, Felix, Figueiredo, Figueiredo, Gatenby, Gillies, Gottlieb, Gow, Hammer, Heffess, Hellerbrand, Jiang, Kavan, Kebebew, Kjellman, Kuhajda, Lacroix, Latronico, Latronico, Liang, Mak, Mendonca, Moir, Nadel, Namer, Pereira, Pouyssegur, Ribeiro, Sambuceti, Sandrini, Sun, Tabarin, Tissier, Tracy, Vander Heiden, Wajapeyee, Weinberg, Weiss, Weldon, Wieand, Yunes, Zambetti, Zerbini   +60 more
core   +2 more sources

Preclinical Cushing's syndrome in adrenal incidentalomas [PDF]

, 1992
Adrenal tumors are usually diagnosed by clinical symptoms of hormone excess. The increasing use of ultrasound and computed tomography results in the detection of a substantial number of incidentally discovered adrenal tumors.
Allolio, B., Krestin, G. P., Nieke, J., Reincke, Martin, Saeger, W., Winkelmann, W.   +5 more
core  

Adrenal lipomatous tumours: a 30 year clinicopathological experience at a single institution [PDF]

, 2001
AIMS: Fatty tumours of the adrenal gland are uncommon and their features have received little attention in the literature. The aim of this study is to analyse the features of adrenal lipomatous tumours.
Lam, AKY, Lo, CY
core   +1 more source

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis

Cancer Communications, EarlyView.
Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM.
Yizhi Zhan, Jinsong Xu, Zhanqiao Zhang, Yating Hu, Yongsheng Li, Junying Qian, Yunyan Ling, Dehua Wu, Haijun Deng, Guoxin Li, Zhiyong Shen, Yuan Fang   +11 more
wiley   +1 more source

Advances in radiopharmaceuticals for cancer radiotheranostics: CCK2R targeting as a paradigm for translational innovation

Cancer Communications, EarlyView.
Abstract Radiopharmaceuticals are reshaping the landscape of cancer therapy, offering a unique theranostic advantage that is becoming increasingly central to precision medicine. By labeling the same molecular scaffold with different radionuclides, these agents enable seamless integration of diagnostic imaging and targeted therapy.
Jing Li, Xuejun Wen, Rebeka Rita Reszegi, Hemavarshini Kamalrhaj, Wolfgang J. Parak, Xiaoyuan Chen, Jingjing Zhang   +6 more
wiley   +1 more source

Symptomatic ovarian steroid cell tumor not otherwise specified in a post-menopausal woman

Rare Tumors, 2016
Steroid cell tumor not otherwise specified (NOS) is a rare subtype of sex cord stromal tumor of the ovary and contributes less than 0.1% of all ovarian neoplasms.
Neha Sood, Kaniksha Desai, Ana-Maria Chindris, Jason Lewis, Tri A. Dinh   +4 more
doaj   +1 more source