Results 231 to 240 of about 117,113 (304)

Clinical implications of PD‐L1 expression in oncogene‐driven NSCLC: Differential responses to targeted agents and immune checkpoint inhibitors

International Journal of Cancer, Volume 159, Issue 1, Page 269-279, 1 July 2026.
What's New? PD‐L1 is a reliable biomarker for predicting immunotherapy efficacy in patients with non‐small‐cell lung cancer lacking oncogenic driver mutations. However, its significance in patients with driver mutations remains unclear. In this study of 273 patients with stage IV non–‐small‐cell lung cancer harboring diverse driver alterations and PD ...
Xiaoxiao Fan, Chenxi Wei, Minjun Rong, Shengnan Wang, Jiaying Wang, Xiaohan Wang, Xiao Han, Xue Meng   +7 more
wiley   +1 more source

Adrenal Primary Ganglioneuroblastoma Presenting in Adulthood: A Case Report

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Ganglioneuroblastoma is a rare neuroblastic tumor derived from embryonic neural crest cells, composed of mature gangliocytes and immature neuroblasts. Although most neuroblastic tumors present in children and commonly involve the adrenal glands, adrenal ganglioneuroblastoma is rare in adults, with only 25 previously reported cases.
Keiichiro Yasuda, Takuji Hayashi, Kentaro Takezawa, Taigo Kato, Koji Hatano, Yoichi Kakuta, Atsunari Kawashima, Eiichi Morii, Norio Nonomura   +8 more
wiley   +1 more source

What Is Your Diagnosis? Splenic Mass in an African Pygmy Hedgehog

Veterinary Clinical Pathology, EarlyView.
Gabriela Hartmann, Milena Carolina Paz, Paola Sônego, Ana Carolina Contri Natal, Lívia Surita, Marcele Bettim Bandinelli, Luciana Sonne   +6 more
wiley   +1 more source

Neuroendocrine Transformation Without PSA Elevation in High‐Risk Metastatic Castration‐Sensitive Prostate Cancer Under Androgen Receptor Signaling Inhibition: A Case Report

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Neuroendocrine prostate cancer is a rare and highly aggressive variant of prostate cancer with a poor prognosis. We report a case in which metastatic castration‐sensitive prostate cancer directly transformed into neuroendocrine prostate cancer without a corresponding increase in prostate‐specific antigen.
Yoshihiro Nakagami, Shintaro Ohnuma, Masashi Tamaoka, Tatsuki Inoue, Motoki Yamagishi, Kazuhiko Oshinomi, Masakazu Nagata, Yasuyuki Oohira, Toshiko Yamochi, Takashi Fukagai   +9 more
wiley   +1 more source

Significant Response to Nivolumab Plus Ipilimumab in Metastatic Mucinous Tubular and Spindle Cell Carcinoma: A Case Report

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare renal cell carcinoma subtype that is typically indolent but may exhibit aggressive behavior. No standard systemic therapy has been established for metastatic MTSCC. Case Presentation A 71‐year‐old woman underwent retroperitoneoscopic radical left nephrectomy for MTSCC ...
Sho Shimasaki, Shinkuro Yamamoto, Mitsuko Iguchi, Erika Yamashita, Kaya Atagi, Yuhei Shiba, Satoshi Fukata, Hirofumi Satake, Takashi Karashima, Keiji Inoue   +9 more
wiley   +1 more source

Ruptured Abdominal Aortic Aneurysm as the Initial Manifestation of Undiagnosed Pheochromocytoma

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Pheochromocytoma is a rare catecholamine‐secreting tumor that can cause severe cardiovascular complications. Its association with ruptured abdominal aortic aneurysm is extremely rare. Case Presentation A 57‐year‐old man with no significant medical history presented with sudden abdominal pain and hemorrhagic shock.
Kyotaro Fukuta, Kohsuke Miyataka, Yuya Hiroshima, Nobuo Satake, Yuichiro Atagi, Keisuke Ozaki, Takeshi Nakashima, Ryoichi Nakanishi, Hirofumi Izaki, Junya Furukawa   +9 more
wiley   +1 more source

Taste and Smell Disturbances Associated With Secondary Adrenal Insufficiency: A Case Report

Journal of General and Family Medicine, Volume 27, Issue 4, July 2026.
ABSTRACT Background Adrenal insufficiency often presents with nonspecific symptoms, impeding early diagnosis. Taste and smell disturbances are rarely recognized as presenting features. Case Presentation We report the case of a 54‐year‐old man with a 3‐month history of persistent taste and smell disturbances accompanied by fatigue, loss of appetite ...
Takanori Izumi, Eri Doi, Yuki Tsutsui, Noboru Horinouchi, Rie Utsunomiya, Katsuhiko Yoshimura, Machiko Morita, Naoki Matsuda, Seiji Shiota   +8 more
wiley   +1 more source

A Phase II Trial of Perioperative Camrelizumab Plus Neoadjuvant Chemotherapy in Resectable Stage IIB–IIIB Lung Squamous Cell Carcinoma

MedComm, Volume 7, Issue 7, July 2026.
This phase II trial suggests the potential of perioperative camrelizumab plus neoadjuvant chemotherapy in patients with resectable stage IIB‐IIIB lung squamous cell carcinoma. The major pathological response rate (primary endpoint) was 60.0%, and the pathological complete response (pCR) rate was 44.4%.
Mingming Hu, Shuku Liu, Yi Han, Feng Wang, Yang Liu, Baohua Lu, Hongxia Li, Yuan Gao, Ying Wang, Wei Yang, Kang Shi, Bo Xiao, Qunhui Wang, Juan Du, Haifeng Lin, Xiaomi Li, Chong Wang, Tongmei Zhang   +17 more
wiley   +1 more source

Granulosa Cell Tumour in a Spayed Cat With Ovarian Remnant Syndrome and Hyperestrogenaemia Without Estrus Signs

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Granulosa cell tumour arising from ovarian remnant tissue can occur in spayed cats without overt estrus signs, despite marked hyperestrogenaemia. In this case, CT showed a large abdominal mass contiguous with ovarian vasculature; surgery and histopathology confirmed granulosa cell tumour with hepatic metastasis.
Hitomi Shinoda, Kenji Mori, Hiroshi Mori, Kumiko Ishigaki, Kazushi Asano   +4 more
wiley   +1 more source