Clinical Practice Patterns in Bone Health Assessment and Management in Endogenous Cushing's Syndrome
ABSTRACT Objective Skeletal fragility is a common complication of endogenous Cushing's Syndrome (CS), although specific guidelines for managing bone health are lacking. This study aimed to assess clinicians' current engagement with bone health assessment and management in patients with endogenous CS. Design Retrospective‐cohort design. Patients Seventy‐
Preeshila Behary +10 more
wiley +1 more source
Resistant arterial hypertension in a patient with adrenal incidentaloma multiple steno-obstructive vascular lesions and antiphospholipid syndrome [PDF]
Resistant hypertension is defined as above of blood pressure (≤ 140/90 mmHg) despite therapy with three or more antihypertensive drugs of different classes at maximum tolerable doses with one bling a diuretic.
CONCISTRE, ANTONIO +8 more
core
New directions for the treatment of adrenal insufficiency [PDF]
The following funding bodies supported this work: Biotechnology and Biological Sciences Research Council (BBSRC BB/L00267/1, to LG), Rosetrees Trust (to LG), Barts and The London Charity (417/2235, to LG), EU COFUND (PCOFUND-GA-2013-608765, to LG and GRB)
Allen +69 more
core +2 more sources
Tyrosine hydroxylase (TH) is a rate‐limiting enzyme for catecholamine synthesis. In this study, we generated a novel Th gene conditional knockout mouse line by crossing Th‐flox mice with Slc6a4‐Cre mice. To our surprise, TH expression was largely lost in the adrenal medulla and sympathetic neurons in the conditional knockout mice.
Ryohei Ogawa +4 more
wiley +1 more source
Participation of the hypophyseal-adrenal cortex system in thrombin clearance during immobilization stress [PDF]
Thrombin marked with I-131 resulted in a considerable increase of the thrombined clearance rate in healthy male rats during stress caused by an immobilization lasting 30 minutes, and in an increase of thrombin clearance occurred by a combination of ...
Bazazyan, G. G. +3 more
core +1 more source
Corticosterone Acts in the Nucleus Accumbens to Enhance Dopamine Signaling and Potentiate Reinstatement of Cocaine Seeking [PDF]
Stressful life events are important contributors to relapse in recovering cocaine addicts, but the mechanisms by which they influence motivational systems are poorly understood.
Baker, David A. +10 more
core +2 more sources
Abstract Adrenal vein sampling (AVS) is the cornerstone diagnostic procedure for subtype differentiation in primary hyperaldosteronism, guiding therapeutic decision‐making and offering the possibility of curative surgery to a subset of patients.
Aura D. Herrera‐Martínez +15 more
wiley +1 more source
P53 mutations in human adrenocortical neoplasms [PDF]
The mechanisms of tumorigenesis of adrenocortical neoplasms have not been elucidated as yet. However, loss of heterozygosity at chromosomal locus 17p has been consistently observed in adrenocortical cancer.
Allolio, B. +6 more
core
Clonal Composition of Human Adrenocortical Neoplasms [PDF]
The mechanisms of tumorigenesis of adrenocortical neoplasms are still not understood. Tumor formation may be the result of spontaneous transformation of adrenocortical cells by somatic mutations.
Abdelhamid, S. +7 more
core
The effects of adrenalectomy and corticsteroid injection on the fibrinolytic activity of complex heparin compounds in the blood during immobilization [PDF]
Total non-enzymatic fibrinolytic activity in the blood of rats increased three times in response to stress caused by 30 minute immobilization, and the activity of epinephrine-heparin complex increased nine times. In adrenalectomized animals, which showed
Kudryashov, B. A. +3 more
core +1 more source

