Results 231 to 240 of about 16,616 (300)

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Efficacy and Safety of Peripheral Nerve Blocks After Arthroscopic Shoulder Surgery: A Systematic Review and Network Meta-Analysis. [PDF]

J Pain Res
Gao Y, Huang J, Liu Z, Hu Z, Yan W, Ren D.   +5 more
europepmc   +1 more source

Casein as rare elicitor of food allergy dependent on augmentation factors ‐ A case report

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Charlotte Jasmin Kiani, Valentina Faihs, Julia Felicitas Pilz, Claudia Kugler, Tilo Biedermann, Knut Brockow   +5 more
wiley   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

[Treatment of acute diabetic metabolic crises in adults (Update 2026)]. [PDF]

Wien Klin Wochenschr
Resl M, Kaser S, Sourij H, Clodi M, Schneeweiß B, Luger A.   +5 more
europepmc   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Nosocomial outbreak of <i>Ralstonia mannitolilytica</i> associated with prefilled saline flush syringes distributed in Europe, Germany, March to September 2026. [PDF]

Euro Surveill
Burdi S, Herrmann L, Koerdt SN, Wolf SA, Appelt S, Sandfort M, Maier B, Reuter S, Hug MJ, Böhm NJ, Karadag G, Berndt G, Dörre A, Schwierzeck V, Behrends L, Kreuzer P, Kuhn J, Murajda L, Roßbach S, Kolbe-Busch S, Seidel C, Jung P, Chanto Chacón G, Zuschneid I, Sedaghatjoo S, Driller Povill M, Scholz HC, Mellmann A, Eckmanns T, Zündorf J, Hogardt M, Haller S.   +31 more
europepmc   +1 more source

DDAVP Challenges in 170 Children With von Willebrand Disease: Response Classification Varies According to Criteria Used

Haemophilia, EarlyView.
ABSTRACT Introduction Individuals diagnosed with types 1/1C/2A/2M von Willebrand disease (VWD) typically undergo a desmopressin (DDAVP) challenge to assess therapeutic benefit. This involves measuring von Willebrand factor antigen (VWF:Ag), activity (VWF:Act; VWF:RCo/VWF:GPIbM/VWF:Ab), and coagulant factor VIII (FVIII:C) levels 0 (pre), 1, and 4‐h post‐
Michael Shu, Caroline Malcolmson, Amanda Fregonas, Tristan E. Knight, Margaret L. Rand, Cindy Wakefield, Vanessa Bouskill, Manuel Carcao   +7 more
wiley   +1 more source

Food-related allergic reactions in a school setting with a strict management plan. [PDF]

Pediatr Allergy Immunol
Piletta-Zanin A, Scherl A, Ortelli D, Edder P, Eigenmann PA.   +4 more
europepmc   +1 more source

Machine Learning Model for Predicting Postoperative Pain in Cases of Irreversible Pulpitis

International Endodontic Journal, EarlyView.
ABSTRACT Aim Postoperative pain is a frequent clinical concern following endodontic treatment. This study aimed to develop and validate supervised machine learning models to predict the occurrence of postoperative pain in cases of irreversible pulpitis.
Pedro Felipe de Jesus Freitas, Ingrid Luiza Mendonça Cunha, Thalita de Paris Matos, Flares Baratto‐Filho, Bianca Marques de Mattos de Araujo, Manoel Damião Sousa‐Neto, Leandro de Moura Martins, Fernando José Herkrath, Emílio Carlos Sponchiado‐Júnior, Cristiano Miranda de Araujo   +9 more
wiley   +1 more source