Results 271 to 280 of about 93,467 (314)

Induction of apoptosis and growth inhibition by silodosin and abiraterone acetate in PC-3 human prostate cancer cells. [PDF]

Investig Clin Urol
Hakim L, Rahman ZA, Hidayatullah F, Ng AC.   +3 more
europepmc   +1 more source

Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications

Journal of Pineal Research, Volume 78, Issue 1, January 2026.
ABSTRACT Gastrointestinal (GI) cancers remain a leading cause of global morbidity and mortality, necessitating novel therapeutic strategies. Melatonin (MEL), an indoleamine with pleiotropic biological activities, has emerged as a promising adjuvant in oncology due to its antiproliferative, proapoptotic, and antioxidant properties.
Maciej Gonciarz, Benita Wiatrak, Iga Lombard, Łukasz Konecki, Joanna Sarbinowska   +4 more
wiley   +1 more source

New Horizons with Growth Differentiation Factor 15 in Oncology: From Cancer Cachexia and Tumour Immunity to Novel Therapeutic Strategies. [PDF]

Curr Oncol
Sugiyama K, Starling N, Chau I.
europepmc   +1 more source

Vagus Nerve Stimulation in Autoimmune Conditions: A Systematic Review

ACR Open Rheumatology, Volume 7, Issue 12, December 2025.
Objective Systemic autoimmune conditions are characterized by increased inflammation and high disease burden. Vagus nerve stimulation (VNS) is known to activate the cholinergic anti‐inflammatory pathway and can serve as a potential therapeutic modality for autoimmune conditions. This study aimed to conduct a preregistered systematic review to determine
Lina E. Lombo, Jorman H. Tejada‐Perdomo, Jorge A. Ramos‐Castaneda, Ronald G. Garcia   +3 more
wiley   +1 more source

Unusual presentation of medication-induced atrial fibrillation: A case report. [PDF]

Clin Case Rep
Hashim T, Yigit Y, Fadul KY, Dayraki M, Elmalik A, Alkahlout BH, Mohammad A.   +6 more
europepmc   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, Volume 12, Issue 47, December 18, 2025.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

The significance of endocannabinoid receptors and endocannabinoids in the lower urinary and genital tract. [PDF]

World J Urol
Ückert S, Hedlund P, Tsikas D, Kuczyk MA.   +3 more
europepmc   +1 more source

Decreased RYR2 Cluster Size and Abnormal SR Ca2+ Release Contribute to Arrhythmogenesis in TMEM43‐Related ARVC

Advanced Science, Volume 12, Issue 45, December 4, 2025.
The TMEM43 ‐ P386S mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC) by mislocalizing itself from nuclear envelope (NE) to cytoplasm, disrupting lamin B2 (a novel TMEM43 interactor) localization, NE integrity and chromatin accessibility, causing hyper ‐ phosphorylation and reduced expression/clustering of ryanodine receptor type 2 (
Jiaxi Shen, Xiaochen Wang, Hangping Fan, Yaxun Sun, Tingyu Gong, Hangyuan Qiu, Jue Wang, Ziwei Pan, Yanna Dang, Hongkun Wang, Danni Zhou, Tianyi Zhu, Hao Wang, Xianzhen Chen, Lizhen Xu, Jun Su, Fan Yang, Yiquan Tang, Xuguang Li, Bing Yang, Lenan Zhuang, Wei Wang, Chenyang Jiang, Ping Liang   +23 more
wiley   +1 more source

Integrated Phytochemical and Pharmacological Assessment of Uraria rufescens Leaves: Insights Into Its Antioxidant, Thrombolytic and CNS Activities

Analytical Science Advances, Volume 6, Issue 2, December 2025.
ABSTRACT Uraria rufescens is traditionally used in Bangladesh for fever and inflammation, yet its phyto‐pharmacological profile was not explored adequately. This investigation exerted the phytochemical composition and pharmacological activities of its leaves methanolic extractives (URME), focusing on in vitro antioxidant and thrombolytic, along with in
Ayesha Siddika Farha, Md. Abdus Samadd, Nahida Akter, Md. Sifat Foysal, Md. Riaz Hossain, Md. Jahid Hossain, Tanvir Hasan, Choudhury Mahmood Hasan, Syed Mohammed Tareq, Mohammed Aktar Sayeed   +9 more
wiley   +1 more source

Cyclohexylamine, the principal metabolite of cyclamate, contracts the epididymal vas deferens of rats by affecting endogenous catecholamine release via postsynaptic α_1A- and presynaptic α₂-adrenoceptors in a calcium-dependent manner. [PDF]

Biomedicine (Taipei)
Chen YF, Wang YW, Tsai HY.
europepmc   +1 more source