Results 281 to 290 of about 93,467 (314)

The Allosteric Mechanism of G‐Protein‐Coupled Receptors is Induced Fit, Not Conformational Selection

BioEssays, Volume 47, Issue 12, December 2025.
Allosteric signaling of G‐protein‐coupled receptors (GPCRs) involves a population shift from inactive to active receptor conformations upon binding of ligand agonists. Kinetic and structural data indicate that this population shift is induced by ligand binding to inactive receptor conformations prior to the conformational change from inactive to active.
Kazem Asadollahi, Paul R. Gooley, Thomas R. Weikl   +2 more
wiley   +1 more source

Development of novel alpha 2B adrenergic receptor ligands by using a palladium catalyzed Buchwald Hartwig amination with a brominated benzodiazepine. [PDF]

RSC Med Chem
Fernando MRT, Vincent AB, Harrington SG, Toriola MA, Medubi KM, Meyer MJ, Webb DA, Arnold LA.   +7 more
europepmc   +1 more source

Novel Insights Into the Bioactive Profile and Therapeutic Potentials of Indonesian Annona muricata Leaves

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
Pharmacological investigation of the aqueous extract of Annona muricata L. leaves from Indonesia. ABSTRACT This study investigates, for the first time, the comprehensive pharmacological profile of the aqueous extract of Annona muricata L. (graviola) leaves from Indonesia, focusing on its antioxidant, antinociceptive, and anti‐inflammatory properties ...
Sara Oufquir, Fatimazahra Agouram, Hamid Kabdy, Mehdi Ait Laaradia, Khadija Oubella, Baslam Abdelmoniim, Aboufatima Rachida, Stefania Garzoli, Abderrahman Chait   +8 more
wiley   +1 more source

Priapism following antipsychotic-gabapentinoid combination in a case of treatment-resistant schizophrenia: a case report. [PDF]

BMC Psychiatry
Haque T, Shastri K, Naguib B, Ayre MJ.
europepmc   +1 more source

Pheochromocytoma with two rare manifestations: Non-ST segment myocardial infarction with normal coronary arteries and blue toe syndrome. [PDF]

SAGE Open Med Case Rep
Mabrouk M, Oueslati I, Cherchir F, Terzi A, Yazidi M, Chihaoui M.   +5 more
europepmc   +1 more source

Impact of physical and psychological stressors on tumor growth and immune responses in breast cancer. [PDF]

Compr Psychoneuroendocrinol
Dees K, Kabir K, Bahani R, Beskow C, Blalock M, Burton E, Kranzlein J, Pierson D, Rice S, Williams M, Dugger KJ.   +10 more
europepmc   +1 more source

Opposite kinetics of L-leucine and L-phenylalanine induced insulin release studies with the perfused rat pancreas [PDF]

, 1972
Landgraf, R., Landgraf-Leurs, M. M. C., Schwarz, K., Scriba, Peter Christian   +3 more
core  

Assessment of Gene Expression on the Gap Junction Connexin of Cumulus Cells on Infertile Women With Polycystic Ovary Syndrome and Poor Ovarian Response: The Novel Role of Propranolol. [PDF]

J Family Reprod Health
Zafari Zangeneh F, Naghizadeh MM, Jafarabadi M, Dehghan M, Bagheri M.   +4 more
europepmc   +1 more source