Results 121 to 130 of about 1,396,034 (289)

Past, Present and Future of Epigenetics in Adrenocortical Carcinoma

Cancers, 2020
DNA methylation profiling has been suggested a reliable technique to distinguish between benign and malignant adrenocortical tumors, a process which with current diagnostic methods remains challenging and lacks diagnostic accuracy of borderline tumors ...
M. Ettaieb, T. Kerkhofs, M. van Engeland, H. Haak   +3 more
semanticscholar   +1 more source

Mosaic Li Fraumeni Syndrome Not Identified in Germinal Tissue

Molecular Genetics &Genomic Medicine, Volume 14, Issue 2, February 2026.
In this study, we presented the first clinical case report of mosaic Li Fraumeni syndrome eluding germinal tissue. This case highlights the complexity of interpreting mosaic variants in TP53, and the difficulty in relaying cancer and reproductive risk information in the context of mosaic Li Fraumeni syndrome.
Rhianna M. Urban, Nisha Kanwar, Megan A. Holdren, Megan F. Hoenig, Laura M. Rust, Myra J. Wick, Matthew J. Ferber, Zhiyv Niu, Sounak Gupta, Wei Shen   +9 more
wiley   +1 more source

Nonfunctioning adrenocortical carcinoma: a study of 12 cases

Journal of Pathology of Nepal, 2012
Background: Adrenal cortical carcinoma is a rare malignant tumor. Several systems were proposed for diagnosis and evaluation of adrenocortical tumors.Weiss system is most commonly used method for assessment of malignancy, but only few studies has applied
S Ghanghoria, P Raje, R Jain, A Ghanghoria   +3 more
doaj   +1 more source

Adrenal insufficiency due to bilateral adrenal metastases - A systematic review and meta-analysis [PDF]

, 2019
Objective: Bilateral adrenal metastases may cause adrenal insufficiency (AI) but it is unclear if screening for AI in patients with bilateral adrenal metastases is justified, despite the potential for adrenal crises. Method: A search using PubMed/Medline,
Falhammar, Henrik, Rushworth, R Louise, Tallis, Philippa H, Torpy, David J   +3 more
core   +1 more source

Adjuvant Radiation Improves Recurrence-Free Survival and Overall Survival in Adrenocortical Carcinoma.

Journal of Clinical Endocrinology and Metabolism, 2019
CONTEXT Adrenocortical carcinoma (ACC) is a rare malignancy with high rates of recurrence and poor prognosis. The role of radiotherapy (RT) in localized ACC has been controversial and is not routinely offered.
L. Gharzai, Michael D. Green, K. Griffith, T. Else, C. Mayo, Elizabeth Hesseltine, D. Spratt, E. Ben-Josef, A. Sabolch, Barbara S Miller, F. Worden, T. Giordano, G. Hammer, S. Jolly   +13 more
semanticscholar   +1 more source

Pneumoperitoneum in two cats treated with trilostane for hypercortisolism

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract This report describes two cases of pneumoperitoneum in cats receiving treatment for hypercortisolism and diabetes mellitus. Both cats presented with abdominal distention and lethargy and diagnoses of pneumoperitoneum were radiographically confirmed.
Nicholas James Kelly, Armando Sánchez‐Lara, Mike E. Herrtage, Hannah Wong, Andre Kortum   +4 more
wiley   +1 more source

Molecular Drivers of Potential Immunotherapy Failure in Adrenocortical Carcinoma

Journal of Oncology, 2019
Adrenocortical carcinoma (ACC) is a rare, highly aggressive cancer, often insensitive to conventional chemotherapeutics agents. Early diagnosis, followed by radical surgical resection plus/minus adjuvant mitotane therapy, is nowadays the only valuable ...
C. Fiorentini, S. Grisanti, D. Cosentini, A. Abate, E. Rossini, A. Berruti, S. Sigala   +6 more
semanticscholar   +1 more source

Clinical significance and immune microenvironment association of cuproptosis‐related genes in pan‐cancer

Experimental Physiology, Volume 111, Issue 2, Page 539-555, 1 February 2026.
Abstract Recent studies highlight the important roles of cuproptosis in cancer cells. However, the roles of the cuproptosis‐related genes (CRGs) in different cancers are still not fully understood. Comprehensive analysis was performed using open‐source bioinformatic platforms to disclose the expression profiles, prognostic significance, genomic and ...
Xinyu Ge, Kaijing Wang, Tian Zhao, Jinyi Wang, Jie Liu, Zhengliang Sun, Zhengjun Chai, Wen Zhang, Chengbao Li, Yan Xu, Guohan Chen   +10 more
wiley   +1 more source

Clinical results of the use of mitotane for adrenocortical carcinoma

Brazilian Journal of Medical and Biological Research, 2000
Mitotane (o,p'-DDD) acts mainly as an inhibitor of intramitochondrial pregnenolone and cortisol synthesis. Its adrenolytic effect depends on metabolic activation due to conversion to o,p'-DDA and o,p'-DDE.
A.A. Kasperlik-Zaluska
doaj   +1 more source

Adrenal pheochromocytoma incidentally discovered in a patient with parkinsonism [PDF]

, 2015
To evaluate the diagnostic route of pheochromocytoma (PHEO) in a patient under dopaminergic treatment. A 70-year-old man with Parkinsonism and under treatment with levodopa and carbidopa came to our observation for evaluation of arterial hypertension and
Claudio Letizia, Concistrè Antonio, Giuseppe De Vincentis, Iannucci Gino, Lucia Piernatale, Luigi Petramala, Marinelli Cristiano, Zinnamosca Laura   +7 more
core   +1 more source