Results 81 to 90 of about 3,137,982 (258)

Adult onset Leigh syndrome

Annals of Indian Academy of Neurology, 2007
Leigh syndrome is a rare progressive mitochondrial disorder of oxidative metabolism. Though it has been reported in infancy and childhood, it is rarely described in adults.
Pandit Lekha, Narayanappa Gayatri, Shetty Lathika, Krishna Sree   +3 more
doaj  

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

, 2017
Background Adult-onset severe asthma is characterized by highly symptomatic disease despite high-intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease is needed for the development of targeted treatments ...
Flemming, Louise J, Chung, Kian Fan, Howarth, Peter H., Shaw, Dominique E., Vissing, Nadja, Fleming, Louise J., Shaw, Dominique E, Auffray, C, U-BIOPRED Study Group, Chung, K. F., Sterk Peter, J., Bansal, Aruna T., Auffray, Charles, Pandis, Yannis, Sousa, Ana R., Pavlidis, Stelios, De Meulder, Bertrand, Loza, Matt J, Adcock, Ian M, Wagener, Ariane H., Howarth, Peter, Bansal, Aruna T, Bates, Steve, Sterk, Peter J, U-BIOPRED, Study Group, Fowler, Stephen J, Bisgaard, Hans, Guo, Y., Zwinderman, Koos, Brinkman, Paul, Corfield, Julie, Hekking, Pieter-Paul, Adcock, Ian M., Thorsen, Jonathan, Zetterquist, Wilhelm, Djukanovic, Ratko, Wen, Yu, Bates, Steve A, Bønnelykke, Klaus, Sterk, Peter J., Loza, Matt J., Wagener, Ariane H, Fowler, Stephen; id_orcid, Sousa, Ana R, Fowler, Stephen J., Bates, Steve A., Lefaudeux, Diane, Fleming, Louise J, Howarth, Peter H, Meiser, Andrea, Adcock, Ian M., Guo, Y, Loza, Matthew J, Sun, Kai, Baribaud, Fred, Lutter, Rene, Chung, K.F., Hekking, Pieter-Paul W, Adcock, I M, Ahmed, H, Bel, Elisabeth H., Bel, Elisabeth H   +61 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Adult-onset type II citrullinemia: Current insights and therapy

, 2018
Kiyoshi Hayasaka,1,2 Chikahiko Numakura1 1Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan; 2Department of Pediatrics, Miyukikai Hospital, Kaminoyama, Japan Abstract: Citrin deficiency is a recessively inherited metabolic
Hayasaka K, Numakura C
core  

Self-evaluations in adult education and training [PDF]

, 2005
This paper focuses on two key aspects of self-evaluation in adult education and training through the perspective of (a) a social-cognitive framework which is used to categorise those factors that enhance self-efficacy and self-evaluation, and (b) the ...
Athanasou, J
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Adult Onset Still's Disease - current state of knowledge

Journal of Education, Health and Sport
Introduction: Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. AOSD lies at the crossroads of innate and adaptive immunity, highlighting the complexity of its pathogenesis.
Anna Centkowska, Natalia Katarzyna Wagner-Bieleń, Martyna Zwierzchowska, Agata Antoniak, Anna Maria Jocz, Joanna Karina Banaśkiewicz, Aleksandra Maria Żyta, Gabriela Helena Dąbrowska, Maria Anna Żmijewska, Jakub Ziółkowski   +9 more
doaj   +1 more source

Adult-onset Still's disease: current challenges and future prospects

, 2016
Mariam Siddiqui,1 Michael S Putman,2 Anisha B Dua,11Department of Rheumatology, 2Department of Internal Medicine, The University of Chicago Medical Center, Chicago, IL, USA Abstract: Adult-onset Still's disease (AOSD) – a multi-systemic ...
Putman MS, Dua AB, Siddiqui M
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source