Results 91 to 100 of about 118,654 (333)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Adult onset Still's disease-The evidence that anti-interleukin-1 treatment is effective and well-tolerated (a comprehensive literature review).

Seminars in Arthritis & Rheumatism, 2017
The literature contains many reports of the use of commercially available anti-IL-1 agents (anakinra/Kineret®, canakinumab/Ilaris®, or rilonacept/Arcalyst®) in treatment-resistant adult-onset Still's disease (AOSD).
G. Junge, J. Mason, E. Feist
semanticscholar   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Non-purulent pharyngitis: adult still’s disease [PDF]

, 2020
 Adult Still’s disease is rare and may present as pyrexia of unknown origin. Due to lack of expertise, diagnosis may be delayed inadvertently. The patient usually presents with spiked fever, polyarthralgia or arthritis, evanescent skin rash, non-purulent
B. V., Nagabhushanarao, Dannana, Naveen Kumar, Konathala, Surendra, Vatti, Narmada   +3 more
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Adult-Onset Still's Disease: A Review

Proceedings of Singapore Healthcare, 2013
Adult-onset Still's disease (AOSD) is an uncommon inflammatory condition characterised by high fever, leukocytosis with neutrophilia, arthralgia and skin rash.
Weng Seng Fong MBBS (Singapore), MRCP (UK), Nai Lee Lui MBBS (Singapore), MRCP (UK) M.Med (Int. Med) Singapore   +1 more
doaj   +1 more source

Summary of Papers Presented at the 45th Annual McGuire Lecture Series [PDF]

, 1974
It is the purpose of this presentation to quickly review some of the important points of the papers which were presented at the 45th Annual McGuire Lecture Series on the subject of immunology and rheumatic ...
Irby, Robert
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Acute liver transplantation in a 41-year-old male patient presenting symptoms of adult-onset Still's disease [PDF]

, 2011
L
Andrès E., Bywaters E.G., Coffernils M., Cush J.J., Fautrel B., Ishikawa M., Kadar J., Linde B., Mehrpoor G., Mert A., Motoo Y., Nemes B., Nemes B., Nemes B., Ogata A., Singh S., Still G.F., Taccone F.S., Takami A., Teran A., Yamaguchi M., Zhu G.   +21 more
core   +2 more sources

Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis.

Clinical Immunology, 2016
To compare pro-inflammatory cytokine profiles and kinetics in patients with adult-onset Still's disease (AOSD) to those in patients with systemic juvenile idiopathic arthritis (s-JIA), we analyzed serum cytokine concentrations in 33 patients with AOSD ...
N. Inoue, M. Shimizu, S. Tsunoda, M. Kawano, M. Matsumura, A. Yachie   +5 more
semanticscholar   +1 more source