Results 101 to 110 of about 118,654 (333)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Autoimmune meningitis and encephalitis in adult-onset still disease – Case report [PDF]

, 1970
Introduction Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown cause. Its symptoms usually include persistent fever, fugitive salmon-colored rash, arthritis, sore throat (not specific), but it may also lead to internal ...
Bożek, Milena, Konopko, Magdalena, Makowicz, Grzegorz, Sienkiewicz-Jarosz, Halina, Wierzba-Bobrowicz, Teresa, Witkowski, Grzegorz   +5 more
core   +2 more sources

Efficacy of Anakinra in Refractory Adult-Onset Still's Disease

Medicine, 2015
Adult-onset Still's disease (AOSD) is often refractory to standard therapy. Anakinra (ANK), an interleukin-1 receptor antagonist, has demonstrated efficacy in single cases and small series of AOSD.
F. Ortiz-Sanjuan, R. Blanco, L. Riancho-Zarrabeitia, S. Castañeda, A. Olivé, A. Riveros, M. Velloso-Feijoó, J. Narváez, I. Jiménez-Moleón, O. Maíz-Alonso, C. Ordóñez, J. Bernal, María V. Hernandez, W. Sifuentes-Giraldo, C. Gómez-Arango, E. Galíndez-Agirregoikoa, J. Blanco-madrigal, V. Ortiz-Santamaria, J. del Blanco-Barnusell, J. R. de Dios, M. Moreno, J. Fiter, M. D. L. Riscos, P. Carreira, María J. Rodriguez-Valls, M. Gonzalez-vela, V. Calvo-Río, J. Loricera, N. Palmou-Fontana, T. Pina, J. Llorca, M. González-Gay   +31 more
semanticscholar   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Clarithromicin in adult-onset Still'disease a study of 6 cases [PDF]

, 2010
Adult-onset Still's disease (AOSD) is a rare rheumatological condition characterized by an acute systemic involvement. There are no treatment guidelines.
Abdi-Ali, L, Baiardi, P, Benucci, M, Bucci, M, Cirino, G, Manfredi, M, Saviola, G   +6 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

The progression of initial symptoms and its relationship with the clinical course in adult-onset Still’s disease: from the KEIO-AOSD cohort

EULAR Rheumatology Open
: Objectives: Adult-onset Still’s disease presents with nonspecific and heterogeneous features. This study aims to elucidate the development of initial symptoms and their relationship with the disease course in adult-onset Still’s disease.
Hiroya Tamai, Jun Kikuchi, Tsutomu Takeuchi, Yuko Kaneko   +3 more
doaj   +1 more source

Anakinra for the treatment of adult-onset Still's disease [PDF]

, 2018
: Introduction: Adult onset Still's disease (AOSD) is an uncommon systemic inflammatory disease on the clinical spectrum of autoinflammatory disorders.
Atienza Mateo, Belén, Castañeda Sanz, Santos, González-Gay Mantecón, Miguel Ángel, Martín Varillas, José Luis, Serra López-Matencio, José María   +4 more
core   +2 more sources

Adult Onset Still's Disease

Faridpur Medical College Journal, 2017
Adult Still's disease is rare disease presented with high spiking fever, joint pain, rash, organomegaly and serositis. It is difficult to diagnose as it closely mimics with many systemic diseases, so it can be diagnosed after exclusion of them. There are lots of diagnostic criteria, of them Yamaguchi's criteria is well established.
MM Shahin Ul Islam, Mst Naznin Sarker, Md Iqbal Hossain, Mohammad Iqbal Hossain, Muhammad Kamruzzaman   +4 more
openaire   +2 more sources

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source