Results 31 to 40 of about 118,654 (333)

Therapy with canakinumab for adult-onset still's disease

Научно-практическая ревматология, 2019
Still's disease in children (systemic-onset juvenile idiopathic arthritis, SoJIA) and in adults (adult-onset Still's disease) are considered as non-familial systemic autoinflammatory diseases of unknown etiology driven by similar immunopathogenetic ...
E. L. Nasonov
doaj   +1 more source

Adult-onset Still's disease with atypical cutaneous manifestations [PDF]

, 2018
The diagnosis of adult-onset Still's disease (AOSD) can be very difficult. There are no specific tests available, and diagnosis is usually based on a symptom complex and the well-described typical evanescent rash seen in the majority of patients. However,
Juarez, Pablo, Jucglà, Anna, López de Recalde, Mercè, Morales-Ivorra, Isabel, Narváez García, Francisco Javier, Nolla Solé, Joan Miquel, Pascual, María   +6 more
core   +1 more source

Development and Role in Therapy of Canakinumab in Adult-Onset Still's Disease [PDF]

, 2018
Adult-onset Still's disease (AOSD) is a rare inflammatory disease of unknown etiology typically characterized by episodes of spiking fever, evanescent rash, arthralgia, leukocytosis, and hyperferritinemia. The pivotal role of interleukin (IL)-1 and other
Baggio, Chiara, Bindoli, S, Galozzi, P, Oliviero, F, Sfriso, P   +4 more
core   +1 more source

Canakinumab for Treatment of Adult-Onset Still’s Disease to Achieve Reduction of Arthritic Manifestation (CONSIDER): phase II, randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial

Annals of the Rheumatic Diseases, 2020
Background Inhibition of interleukin (IL)-1 represents a promising treatment option in adult-onset Still's disease (AOSD). Objective To investigate the efficacy and safety of canakinumab in patients with AOSD and active joint involvement by means of a ...
C. Kedor, J. Listing, J. Zernicke, A. Weiß, F. Behrens, N. Blank, J. Henes, J. Kekow, A. Rubbert-Roth, H. Schulze-Koops, E. Seipelt, C. Specker, E. Feist   +12 more
semanticscholar   +1 more source

Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still’s disease

Annals of the Rheumatic Diseases, 2017
Objectives Adult-onset Still’s disease (AOSD) is a rare systemic autoinflammatory disease; its management is largely empirical. This is the first clinical study to determine if interleukin (IL)-18 inhibition, using the recombinant human IL-18 binding ...
C. Gabay, B. Fautrel, J. Rech, F. Spertini, E. Feist, I. Kötter, E. Hachulla, J. Morel, T. Schaeverbeke, M. Hamidou, T. Martin, B. Hellmich, P. Lamprecht, H. Schulze-Koops, D. Courvoisier, A. Sleight, E. Schiffrin   +16 more
semanticscholar   +1 more source

Elevated Troponin Serum Levels in Adult Onset Still's Disease [PDF]

, 2015
Adult onset Still's disease (AOSD) is a rare inflammatory systemic disease that occasionally may affect myocardium. Diagnosis is based on typical AOSD symptoms after the exclusion of well-known infectious, neoplastic, or autoimmune/autoinflammatory ...
Brugioni, Lucio, COLACI, Michele, FERRI, Clodoveo, Giuggioli, Dilia, Manzini, Carlo Umberto, SEBASTIANI, Marco, SPINELLA, AMELIA, Tognetti, Maurizio   +7 more
core   +3 more sources

Tocilizumab in patients with adult-onset still’s disease refractory to glucocorticoid treatment: a randomised, double-blind, placebo-controlled phase III trial

Annals of the Rheumatic Diseases, 2018
Objective To evaluate the efficacy and safety of tocilizumab, an interleukin-6 receptor antibody, in patients with adult-onset Still’s disease. Methods In this double-blind, randomised, placebo-controlled phase III trial, 27 patients with adult-onset ...
Y. Kaneko, H. Kameda, K. Ikeda, T. Ishii, K. Murakami, H. Takamatsu, Yoshiya Tanaka, T. Abe, T. Takeuchi   +8 more
semanticscholar   +1 more source

Clinical Phenotypes of Adult-Onset Still’s Disease: New Insights from Pathophysiology and Literature Findings

Journal of Clinical Medicine, 2021
Adult-onset Still’s disease (AOSD) is a non-familial, polygenic systemic autoinflammatory disorder. It is traditionally characterized by four cardinal manifestations—spiking fever, an evanescent salmon-pink maculopapular rash, arthralgia or arthritis and
S. Mitrovic, B. Fautrel
semanticscholar   +1 more source

Adult-onset Still's Disease: A Case Report

Journal of Nepal Medical Association, 2020
Adult-onset Still’s Disease is a rare auto inflammatory disorder of unknown etiology characterized mainly by high spiking fever, arthritis, evanescent rash and lymphadenopathy.
Ashok Sapkota, Nirdesh Pokhrel, Jayaram Adhikari, Bishal Shrestha, Yoveen Kumar Yadav   +4 more
doaj   +1 more source

Persistent pruritic papules and plaques: a characteristic histopathologic presentation seen in a subset of patients with adult-onset and juvenile Still's disease [PDF]

, 2010
Background: ‘Persistent pruritic papules and plaques' of Still's disease represents a recently described eruption seen in a subset of patients. Most cases reported in the literature to date have been associated with adult-onset Still's disease.
Affleck, Bywaters, Fautrel, Lee, Lűbbe, Mehrpoor, Prendiville, Ravelli, Suzuki, Wolgamot   +9 more
core   +1 more source