Results 61 to 70 of about 4,345 (272)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Hepatic tuberculosis presenting with extreme hyperferritinemia masquerading as adult-onset Still’s disease: a case report

Journal of Medical Case Reports, 2012
Introduction Isolated hepatic tuberculosis is an uncommon manifestation of one of the most common infections worldwide, caused by Mycobacterium tuberculosis. Extremely high serum ferritin, which is regarded as a marker of adult onset Still’s disease, has
Manoj Edirisooriya, Srigrishna Rajini, Ragunathan Murugapillai K   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Adult-onset Still's disease: Clinical cases

Современная ревматология, 2014
The annual incidence of adult-onset Still's disease (AOSD) worldwide is 0.16 cases per 100,000 persons. Its leading symptoms are joint involvement, fever, skin rash, and neutrophilic leukocytosis in the absence of rheumatoid factor and anticyclic ...
G. R. Imametdinova, N. V. Chichasova
doaj   +3 more sources

Molecular mechanisms in idiopathic inflammatory myopathies [PDF]

, 2014
Background: Myositis is a group of rare autoimmune diseases. Muscle weakness and fatigue are the dominant symptoms and inflammation with T cells and macrophages is a characteristic finding in muscle tissue.
Zong, Mei
core   +1 more source

Adult-onset Still's disease following COVID-19 vaccination [PDF]

, 2021
N/
Bosello, Silvia Laura (ORCID:0000-0002-4837-447X), Cerasuolo, Pier Giacomo, Cocciolillo, Fabrizio, D'Agostino, Maria Antonietta (ORCID:0000-0002-5347-0060), Fiori, Enrica, Leone, Flavia, Merlino, Biagio (ORCID:0000-0003-1104-3463), Verardi, Lucrezia, Zoli, Angelo (ORCID:0000-0003-1597-058X)   +8 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Hemophagocytic lymphohistiocytosis accompanying Still's disease: A case report

Clinical Case Reports, 2023
Key Clinical Message Hemophagocytic lymphohistiocytosis (HLH) is a rare hematologic disease that occurs due to immune system dysfunction. Clinical manifestations of this disease are fever, increased ferritin level, cytopenia, and hemophagocytosis in the ...
Arman Ahmadzadeh, Neda Babadi, Faraneh Farsad, Saba Babadi, Shirin Assar   +4 more
doaj   +1 more source

The CD68+/H-ferritin+ cells colonize the lymph nodes of the patients with adult onset Still's disease and are associated with increased extracellular level of H-ferritin in the same tissue: Correlation with disease severity and implication for pathogenesis [PDF]

, 2015
In this work, we aimed to evaluate the levels of ferritin enriched in H subunits (H-ferritin) and ferritin enriched in L subunits (L-ferritin) and the cells expressing these two molecules in the lymph node (LN) biopsies obtained from adult-onset Still's ...
Berardicurti, O., Carubbi, F., CICCIA, Francesco, Cipriani, P., Di Benedetto, P., Giacomelli, R., GUGGINO, Giuliana, Liakouli, V., Rizzo, A., Ruscitti, P., TRIOLO, Giovanni   +10 more
core   +1 more source