Results 71 to 80 of about 118,654 (333)

Derivation and validation of four patient clusters in Still's disease, results from GIRRCS AOSD-study group and AIDA Network Still Disease Registry [PDF]

, 2023
Background Different patient clusters were preliminarily suggested to dissect the clinical heterogeneity in Still's disease. Thus, we aimed at deriving and validating disease clusters in a multicentre, observational, prospective study to stratify these ...
Alibaz-Oner F., Almaghlouth I. A., Antonelli I. P. D. B., Asfina K., Atzeni F., Bartoloni E., Berardicurti O., Bugatti S., Caggiano V., Cantarini L., Carubbi F., Caso F., Ciccia F., Cipriani P., Costa L., Dagna L., De Stefano L., Del Giudice E., Di Cola I., Di Muzio C., Direskeneli H., Emmi G., Erten S., Fabiani C., Fotis L., Frediani B., Giacomelli R., Giardini H., Gidaro A., Govoni M., Guggino G., Hernandez-Rodriguez J., Hinojosa-Azaola A., Iacono D., Iagnocco A., La Torre F., Lo Gullo A., Lopalco G., Maggio M. C., Maier A., Makowska J., Martin-Nares E., Masedu F., Mauro D., Montecucco C., Monti S., Navarini L., Ogunjimi B., Pantano I., Perosa F., Prete M., Ragab G., Rossi S., Ruscitti P., Sevik G., Sfikakis P. P., Sfriso P., Simonini G., Tharwat S., Torres-Ruiz J., Tufan A., Valenti M., Vitale A.   +62 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Adult-Onset Still’s Disease (AOSD): Advances in Understanding Pathophysiology, Genetics and Emerging Treatment Options

Drugs
Adult-onset Still’s disease (AOSD) is a multisystemic complex disorder clinically characterised by episodes of spiking fever, evanescent rash, polyarthritis or diffuse arthralgias; multiorgan involvement may develop according to the hyper-inflammatory ...
S. Bindoli, Chiara Baggio, A. Doria, P. Sfriso   +3 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study [PDF]

, 2016
Objectives: The objectives of this study were to examine changes in incidence and prevalence of RA between 1990 and 2014, and to explore if there is any geographic variation in incidence and prevalence of RA in the UK Methods: Design Prospective ...
Abhishek Abhishek, Chang-Fu Kuo, Christian D. Mallen, Drosos, Dugowson, Entezami, Jacobsson, Kaipiainen-Seppanen, Kaipiainen-Seppanen, Kaipiainen-Seppänen, Lee, Matthew J. Grainge, Michael Doherty, Nicholson, Silman, Weiya Zhang, Widdifield, Widdifield   +17 more
core   +3 more sources

New-onset Adult-onset Still’s disease-like syndrome after ChAdOx1 nCoV-19 vaccination—a case series with review of literature

Clinical Rheumatology, 2022
We report a series of 3 Adult-onset Still’s disease (AOSD)-like presentations in previously healthy females following vaccination with the ChAdOx1 nCoV-19 vaccine, and also compare them with similar cases reported in literature through a PubMed database ...
Shivraj Padiyar, Navaneeth Kamath, J. Mathew, A. Chandu, D. Deodhar, B. Shastry, T. Shashikala, Arvind Ganapati   +7 more
semanticscholar   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Septic arthritis or adult-onset still’s disease: analyzing the causes of recurrent fever after arthroscopic combined anterior cruciate ligament and posterior cruciate ligament reconstruction: a case report

BMC Musculoskeletal Disorders
Background Adult-onset still’s disease and septic arthritis share similar symptoms—fever, joint pain, and limited mobility—making postoperative diagnosis difficult after combined anterior cruciate ligament and posterior cruciate ligament reconstruction ...
Zenan Tian, Jianlong Ni, Wang Wei, Qichun Song, Shanshan Liu, Dongjian Wang, Ruiying Li, Dazhi Wang, Zhihao Chen, Zhikun Jia, Jiajun Jiang, Zhibin Shi   +11 more
doaj   +1 more source

Noncaseating suppurative granulomatous lymphadenitis in adult onset Still’s disease – a diagnostic dilemma in a tuberculosis-endemic region: a case report

Journal of Medical Case Reports, 2018
Background Lymphadenopathy is not an uncommon presentation of adult onset Still’s disease: it is present in up to two thirds of patients with adult onset Still’s disease.
S. W. G. J. W. Chinthaka, R. L. Satarasinghe, S. Senanayake, W. A. P. S. R. Weerarathne, A. A. M. Anfaz, M. P. Deraniyagala   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source