Results 101 to 110 of about 3,601,991 (269)

A qualitative study exploring critical care survivors’ and their clinicians’ shared experiences of navigating a fragmented care system

Scientific Reports
Recovery following a critical illness is challenging. Follow-up clinic provision is standard of care, but the effectiveness of services remain unclear, with some data demonstrating limited or potential detrimental effects. While the patients’ perspective
Saira Nazeer, Georgia Mathieson, Zudin Puthucheary, Timothy J. Stephens   +3 more
doaj   +1 more source

Theory of mind’s studies of the adults, by the adults, for the adults

The Proceedings of the Annual Convention of the Japanese Psychological Association, 2014
Kaoru Toyama, Yukio Maehara, Yuki Otsuka, Fumikazu Furumi, Shoji Itakura, Michiteru Kitazaki   +5 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Let’s get in sync: current standing and future of AI-based detection of patient-ventilator asynchrony

Intensive Care Medicine Experimental
Background Patient-ventilator asynchrony (PVA) is a mismatch between the patient’s respiratory drive/effort and the ventilator breath delivery. It occurs frequently in mechanically ventilated patients and has been associated with adverse events and ...
Thijs P. Rietveld, Björn J. P. van der Ster, Abraham Schoe, Henrik Endeman, Anton Balakirev, Daria Kozlova, Diederik A. M. P. J. Gommers, Annemijn H. Jonkman   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Patient–ventilator synchrony under non-invasive ventilation is improved by an automated real time waveform analysis algorithm: a bench study

Intensive Care Medicine Experimental
Background Because of inherent leaks, obtaining good patient–ventilator synchrony during non-invasive ventilation (NIV) is challenging. The IntelliSync + ® software (Hamilton medical, Bonaduz, CH), that can be used together with the NIV mode, performs ...
Yann Renaud, Jocelyne Auroi, Davy Cabrio, Ermes Lupieri, Jean-Daniel Chiche, Lise Piquilloud   +5 more
doaj   +1 more source