Results 131 to 140 of about 7,694,085 (317)

On the other side of the table: Lessons from the administrator-cum-adult learner [PDF]

, 2007
This paper addresses the issue on the changing management and leadership roles of the school administrators as they participate in a tertiary learning program as adult learners.
Abd Majid, Faizah, Ibrahim, Abu Bakar
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Let’s get in sync: current standing and future of AI-based detection of patient-ventilator asynchrony

Intensive Care Medicine Experimental
Background Patient-ventilator asynchrony (PVA) is a mismatch between the patient’s respiratory drive/effort and the ventilator breath delivery. It occurs frequently in mechanically ventilated patients and has been associated with adverse events and ...
Thijs P. Rietveld, Björn J. P. van der Ster, Abraham Schoe, Henrik Endeman, Anton Balakirev, Daria Kozlova, Diederik A. M. P. J. Gommers, Annemijn H. Jonkman   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Determining the Relationship Between Perceptions of Nursing Care Quality and Satisfaction Status in Multicultural Patients with Hematological Malignancies

Florence Nightingale Journal of Nursing
AIM: This study aims to investigate the correlation between multicultural patients with hematologic malignancies’ perceptions of nursing care and their level of satisfaction, with the objective of providing recommendations for enhancing the quality of ...
Sevinç Selçuk, Seçkin Erdal, Elif Begüm Şimşek-Hanpa, Zeynep Gökçe Dede, Elif İnanlı   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Patient–ventilator synchrony under non-invasive ventilation is improved by an automated real time waveform analysis algorithm: a bench study

Intensive Care Medicine Experimental
Background Because of inherent leaks, obtaining good patient–ventilator synchrony during non-invasive ventilation (NIV) is challenging. The IntelliSync + ® software (Hamilton medical, Bonaduz, CH), that can be used together with the NIV mode, performs ...
Yann Renaud, Jocelyne Auroi, Davy Cabrio, Ermes Lupieri, Jean-Daniel Chiche, Lise Piquilloud   +5 more
doaj   +1 more source

'Right I can do this now'. Community based adult learning, health and well-being [PDF]

, 2014
This article explores the experiences of participants in community based adult learning (CBAL) in relation to health and well-being. It draws on data from a small-scale life history study undertaken with 10 adult learners in two local authority areas in ...
McIntyre, Janis
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source