Results 161 to 170 of about 8,262,084 (314)

Clinical course and pathogenicity of variant rabbit haemorrhagic disease virus in experimentally infected adult and kit rabbits: Significance towards control and spread

, 2018
Kevin P. Dalton, Ana Balseiro, Ramón A. Juste, Ana Podadera, Inés Nicieza, Del Llano, Roxana González, JoséM. Martín Alonso, José M. Prieto, Francisco Parra, Rosa Casais   +10 more
openalex   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Correlation between worsening pneumonitis and right ventricular systolic function in critically ill patients with COVID-19

Echo Research and Practice
Background The pneumonitis associated with coronavirus disease 2019 (COVID-19) infection impacts the right ventricle (RV). However, the association between the disease severity and right ventricular systolic function needs elucidation.
Hazem Lashin, Jonathan Aron, Shaun Lee, Nick Fletcher   +3 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Perspectives on creative well-being of older adults

, 2023
Dohee Lee, Inkeri Aula, Masood Masoodian
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

vvECMO can be avoided by a transpulmonary pressure guided open lung concept in patients with severe ARDS

Critical Care, 2019
Philip van der Zee, Dinis Dos Reis Miranda, Han Meeder, Henrik Endeman, Diederik Gommers   +4 more
doaj   +1 more source

Hospital admissions for hyperglycemic emergencies in young adults at an inner-city hospital

, 2019
Rachel A. Wolf, J. Sonya Haw, Sudeshna Paul, Melissa Spezia Faulkner, EunSeok Cha, MK Findley, Farah Khan, Sara Markley Webster, Anastasia‐Stefania Alexopoulos, Komal Mehta, David Alfa, Mohammed K. Ali   +11 more
openalex   +2 more sources

Personality and mentalization: A latent profile analysis of mentalizing problematics in adult patients

, 2022
Giulia Gagliardini, Salvatore Gullo, Arianna Teti, Antonello Colli   +3 more
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source