Results 231 to 240 of about 11,441,017 (408)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Experimental validation of a rearing protocol for laboratory assays utilizing Osmia lignaria Say (Hymenoptera: Megachilidae). [PDF]

J Insect Sci
Williams MF, Boyle NK, Schaeffer RN, Cox-Foster DL.   +3 more
europepmc   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

A nationwide comparative study of pediatric and adult intussusception in emergency departments during the COVID-19. [PDF]

Sci Rep
Kim DU, Gim H, Chung EH.
europepmc   +1 more source

X-RAY EXPERIMENTS WITH MOLGULA MANHATTENSIS: ADULT SENSITIVITY AND INDUCED ZYGOTIC LETHALITY

, 1957
Daniel S. Grosch, Zoe H. Smith
openalex   +2 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Single-cell atlas of human pediatric liver reveals age-related hepatic gene signatures. [PDF]

Hepatol Commun
Edgar RD, Nakib D, Camat D, Chung S, Lumanto P, Atif J, Perciani CT, Ma XZ, Thoeni C, Selvakumaran N, Manuel J, Sayed B, Huysentruyt K, Ricciuto A, McGilvray I, Avitzur Y, Bader GD, MacParland SA.   +17 more
europepmc   +1 more source

An anatomically comprehensive atlas of the adult human brain transcriptome

Nature, 2012
M. Hawrylycz, E. Lein, A. Guillozet‐Bongaarts, E. Shen, Lydia Ng, Jeremy A. Miller, L. N. V. D. Lagemaat, Kimberly A. Smith, Amanda J. Ebbert, Z. Riley, Chris Abajian, C. Beckmann, Amy Bernard, Darren Bertagnolli, A. Boe, P. Cartagena, M. Chakravarty, Mike Chapin, Jimmy Chong, R. Dalley, B. Daly, Chinh Dang, S. Datta, N. Dee, Tim Dolbeare, V. Faber, David Feng, David R. Fowler, Jeff Goldy, B. Gregor, Zeb Haradon, D. Haynor, J. Hohmann, S. Horvath, Robert E. Howard, A. Jeromin, Jayson M. Jochim, M. Kinnunen, C. Lau, E. Lazarz, Changkyu Lee, Tracy A. Lemon, Lingling Li, Yang Li, J. Morris, C. Overly, Patrick D. Parker, Sheana E. Parry, M. Reding, J. Royall, J. Schulkin, P. A. Sequeira, C. Slaughterbeck, Simon C. Smith, Andrew Sodt, S. Sunkin, B. Swanson, M. Vawter, Derric Williams, Paul E. Wohnoutka, H. Zielke, D. Geschwind, P. Hof, Stephen M. Smith, Christof Koch, S. Grant, Allan R. Jones   +66 more
semanticscholar   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Evaluating the transstadial effects of Bacillus velezensis and pyriproxyfen, alone and in combination, on fitness-related traits of Culex quinquefasciatus. [PDF]

Parasit Vectors
Alomar AA, Alto BW.
europepmc   +1 more source