Results 51 to 60 of about 4,648,112 (319)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

COVID-19 related familial economic disruptions and eating disorder patients’ mental health concerns and motivation to recover

Journal of Eating Disorders, 2022
Plain English summary Following the adoption of stay-at-home regulations to curb the spread of the COVID-19 pandemic, children’s hospitals and emergency rooms across the United States saw a tremendous uptick in adolescents and young adults with eating ...
Monique Santoso, Carly E. Milliren, Elizabeth R. Woods, Sara F. Forman, Tracy K. Richmond   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Patterns of prescribing hydroxyurea for sickle cell disease patients from a central hospital, Saudi Arabia

Hematology Reports, 2019
Sickle cell disease (SCD) is a group of inherited disorders of hemoglobin synthesis. It is prevalent in different parts of the world, including the Kingdom of Saudi Arabia.
Assem A. Elghazaly, Adel A. Aljatham, Abdulaziz M. Khan, Rasha M. Elneil, S. Zubair S. Jafar, Salah A. Elwishy, Omsalma E. Ahmed, Aamer M. Bughnah, Mamoun H. Ibrahim   +8 more
doaj   +1 more source

Group Post-Admission Cognitive Therapy for Suicidality vs Individual Supportive Therapy for the prevention of repeat suicide attempts: a randomized controlled trial

Trials, 2020
Background Suicide is a serious public health problem. The development and use of effective treatments for people hospitalized for suicide attempts remain a priority.
Laurent S. Chaïb, Jorge Lopez-Castroman, Mocrane Abbar   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Effect of preoperative right ventricular dysfunction and dilatation on survival after left ventricular surgical restoration

The Cardiothoracic Surgeon
Background This study investigated the impact of preoperative right ventricular (RV) dysfunction and dilatation on survival outcomes following left ventricular surgical restoration (LVSR) in patients with ischemic cardiomyopathy. A retrospective analysis
Abdelhameed Elsayed, Murtadha H. Alawami, Ismail M. Elnaggar, Tamer N. Mohamed, Musab Kiddo, Mostafa A. Shalaby, Khaled A. Alotaibi, Amr A. Arafat   +7 more
doaj   +1 more source