Results 71 to 80 of about 1,616,423 (295)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Prevalence of adult attention deficit hyperactivity disorder in patients of alcohol dependence syndrome: A cross-sectional study

Industrial Psychiatry Journal
Background: Alcohol use disorders (AUDs) are among the most common comorbid psychiatric disorders in patients with adult attention deficit hyperactivity disorder (ADHD), and adult ADHD is an independent risk factor for developing AUD.
Rishabh Singh, Kaushik Chatterjee, VS Chauhan   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Regional analysis of UK primary care prescribing and adult service referrals for young people with attention-deficit hyperactivity disorder

BJPsych Open, 2020
BackgroundApproximately 20% of children with attention-deficit hyperactivity disorder (ADHD) experience clinical levels of impairment into adulthood. In the UK, there is a sharp reduction in ADHD drug prescribing over the period of transition from child ...
Anna Price, Tamsin Ford, Astrid Janssens, Andrew James Williams, Tamsin Newlove-Delgado   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The relationship between harming behavior and substance use profile, and attention deficit hyperactivity disorder symptoms in antisocial personality disorder [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2017
Objective: The aim of this study was to investigate the relationship between substance use and harming behavior profile, and attention deficit hyperactivity disorder (ADHD) symptoms in young adult male population diagnosed with antisocial personality ...
onur durmaz
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Temperament traits and ADHD subtypes in adults

Object: This study examines ADHD subtypes in adulthood based on temperament dimensions. Temperament reflects stable individual differences in emotional, motor, and attentional reactivity, as well as self-regulation, shaping behavior and personality ...
Heinze, Henning, Daseking, Monika, Kerner auch Körner, Julia, Teuchert, Clara   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source