Results 71 to 80 of about 3,728,881 (306)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Further evidence of the Diagnostic Utility of the Child Behavior Checklist for identifying pediatric Bipolar I Disorder [PDF]

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2019
Amy Yule, Maura Fitzgerald, Timothy Wilens, Janet Wozniak, K. Yvonne Woodworth, Alexa Pulli, Mai Uchida, Stephen V. Faraone, Joseph Biederman   +8 more
doaj   +1 more source

Prevalence of adult attention deficit hyperactivity disorder in patients of alcohol dependence syndrome: A cross-sectional study

Industrial Psychiatry Journal
Background: Alcohol use disorders (AUDs) are among the most common comorbid psychiatric disorders in patients with adult attention deficit hyperactivity disorder (ADHD), and adult ADHD is an independent risk factor for developing AUD.
Rishabh Singh, Kaushik Chatterjee, VS Chauhan   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Regional analysis of UK primary care prescribing and adult service referrals for young people with attention-deficit hyperactivity disorder

BJPsych Open, 2020
BackgroundApproximately 20% of children with attention-deficit hyperactivity disorder (ADHD) experience clinical levels of impairment into adulthood. In the UK, there is a sharp reduction in ADHD drug prescribing over the period of transition from child ...
Anna Price, Tamsin Ford, Astrid Janssens, Andrew James Williams, Tamsin Newlove-Delgado   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Establishing US norms for the Adult ADHD Self‐Report Scale (ASRS‐v1.1) and characterising symptom burden among adults with self‐reported ADHD

International journal of clinical practice, 2018
To estimate Adult ADHD Self‐Report Scale (ASRS‐v1.1) Symptom Checklist normative total scores among the US adult general population and to evaluate overall attention‐deficit hyperactivity disorder (ADHD) symptom burden among US adults with ADHD.
L. Adler, S. Faraone, P. Sarocco, N. Atkins, A. Khachatryan   +4 more
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The relationship between harming behavior and substance use profile, and attention deficit hyperactivity disorder symptoms in antisocial personality disorder [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2017
Objective: The aim of this study was to investigate the relationship between substance use and harming behavior profile, and attention deficit hyperactivity disorder (ADHD) symptoms in young adult male population diagnosed with antisocial personality ...
onur durmaz
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source