Results 211 to 220 of about 19,190,753 (253)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

The transition of youth with diabetes from paediatric to adult diabetes care services: a consensus report of the joint working group of the International Society for Pediatric and Adolescent Diabetes (ISPAD), the European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA).

Horm Res Paediatr
de Beaufort C, James S, Weissberg-Benchell J, Gomber A, Cudizio L, Maruthur NM, Lyons S, Snoek F, Ng SM, Araszkiewicz A, Toft EH.   +10 more
europepmc   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Urban-rural and comorbidity-related differences in vaccination attitudes and self-reported adverse events following immunisation in Poland: a cross-sectional primary care study. [PDF]

Front Public Health
Stefanicka-Wojtas D, Rusiecka A, Hikawczuk T, Soll-Morka A, Kasprzyk-Smardz M, Zadka M, Zachara N, Zachara J, Kurpas D.   +8 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Supporting Aging in Place: A Relational and Preventive Approach to Integrated Care in Naturally Occurring Retirement Communities. [PDF]

Int J Integr Care
Hahn-Goldberg S, Recknagel J, Chang M, Raymond C, Brunner K, Huang MY, Bleah P, Macpherson A, Remark A, Williams L, Patille R, Yue S, Abrams H.   +12 more
europepmc   +1 more source

Partnering With Lived Experience Experts to Co-Design and Co-Facilitate Trauma-Informed Practice Training for Health Professionals: Evaluation Findings. [PDF]

Health Expect
Ciftci S, Heward-Belle S, Pryor N, Luu B, Mayjor H, Freeman P, Rees F, Lovell R.   +7 more
europepmc   +1 more source

Sign language ideologies in deaf education in Trinidad and Tobago. [PDF]

J Deaf Stud Deaf Educ
Dhanoolal I, Snoddon K.
europepmc   +1 more source