Results 61 to 70 of about 19,190,753 (253)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Biology - Stage 2: Laboratory Rules
, 2011 The Institute for Adult Education in Tanzania developed a Multimedia Strategy to assist them to achieve its Mission ‘to design and implement quality adult and continuing education and training programmes that will enable its learners to acquire knowledge
core +1 more source
Residence Heads as Intentional Role‑Players in Promoting Student Success
Journal of Student Affairs in Africa, 2019 Research evidence suggests that approaches to promote student success in higher education are becoming more holistic and integrated in nature. This implies that not only classrooms and laboratories, but also residences, as informal out-of-class learning ...
Johan Groenewald, Magda Fourie-Malherbe
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
ANDRAGOGY OF DEVELOPMENT: BASIC THEOREMS
Образование и наука, 2016 The article presents criticism of the state of scientific knowledge about adult education and provides the reasons for the choice of directions of its development.Methods.
A. G. Teslinov
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Nurse Education Centre, Eastern Health Board: report 1987/88 [PDF]
, 1988 Following the recommendations of the Project Group the Central Nurse Training School opened on 1st, September, 1987, a month earlier than anticipated, with Mr Sean Murphy Chief Nursing Officer as Director.
Eastern Health Board. Nurse Education Centre.
core
Biology - Stage 2: Process of Life
, 2011 The Institute for Adult Education in Tanzania developed a Multimedia Strategy to assist them to achieve its Mission ‘to design and implement quality adult and continuing education and training programmes that will enable its learners to acquire knowledge
core +1 more source