Results 61 to 70 of about 5,087,471 (302)

Prediction of Adult Height by Machine Learning Technique

The Journal of Clinical Endocrinology & Metabolism, 2021
Abstract Context Prediction of AH is frequently undertaken in the clinical setting. The commonly used methods are based on the assessment of skeletal maturation. Predictive algorithms generated by machine learning, which can already automatically drive cars and recognize spoken language, are the keys ...
Michael Shmoish, Alina German, Nurit Devir, Anna Hecht, Gary Butler, Aimon Niklasson, Kerstin Albertsson-Wikland, Ze’ev Hochberg   +7 more
openaire   +2 more sources

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Adult Height and Risk of Colorectal Cancer: A Pooled Analysis of 10 Population-based Cohort Studies in Japan

Journal of Epidemiology
Background: While tall stature has been linked to an increase in the risk of colorectal cancer (CRC), its association with cancer in the colorectum and its subsites remains unclear among Asians.
Rachana Manandhar Shrestha, Tetsuya Mizoue, Zobida Islam, Yukino Kawakatsu, Hidemi Ito, Keiko Wada, Chisato Nagata, Ling Zha, Tetsuhisa Kitamura, Ritsu Sakata, Takashi Kimura, Yumi Sugawara, Ichiro Tsuji, Ren Sato, Norie Sawada, Shoichiro Tsugane, Yingsong Lin, Isao Oze, Sarah Krull Abe, Manami Inoue   +19 more
doaj   +1 more source

The influence of childhood asthma on adult height: evidence from the UK Biobank

BMC Medicine, 2022
Background To elucidate the influence of childhood asthma on adult height after consideration of genetic heterogeneity in height. Methods Based on the UK Biobank, we conducted a matched cohort study, including 13,602 European individuals with asthma ...
Wenwen Chen, Huazhen Yang, Can Hou, Yajing Sun, Yanan Shang, Yu Zeng, Yao Hu, Yuanyuan Qu, Jianwei Zhu, Fang Fang, Donghao Lu, Huan Song   +11 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Agreement between measured height, and height predicted from published equations, in adult South African patients

The South African Journal of Clinical Nutrition, 2022
Objectives: Estimation equations based on different body segments are commonly used to predict height in patients whose height cannot be directly measured.
Hanna Williamson, Corinna Walsh, Mariette Nel, Louise van den Berg   +3 more
doaj   +1 more source

Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses

PLoS Medicine, 2016
Background Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results.
Nikhil K. Khankari, X. Shu, W. Wen, P. Kraft, S. Lindström, U. Peters, J. Schildkraut, F. Schumacher, P. Bofetta, A. Risch, H. Bickeböller, C. Amos, D. Easton, R. Eeles, S. Gruber, C. Haiman, D. Hunter, S. Chanock, B. Pierce, W. Zheng   +19 more
semanticscholar   +1 more source

Height and Adult Alcohol Consumption

Atlantic Economic Journal, 2020
Previous research has found that shorter men have significantly worse life outcomes than taller men. Using the 1979 version of the National Longitudinal Survey of Youth, this paper uses maximum likelihood estimations to test whether these worse outcomes translate into shorter men drinking more heavily.
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source