Results 71 to 80 of about 5,087,471 (302)
Defining the role of common variation in the genomic and biological architecture of adult human height
Nature Genetics, 2014 Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height.A. Wood, T. Esko, Jian Yang, S. Vedantam, T. Pers, S. Gustafsson, Audrey Y. Chu, K. Estrada, J. Luan, Z. Kutalik, N. Amin, Martin L. Buchkovich, Damien C. Croteau-Chonka, F. Day, Y. Duan, T. Fall, R. Fehrmann, T. Ferreira, A. Jackson, J. Karjalainen, K. S. Lo, A. Locke, R. Mägi, E. Mihailov, E. Porcu, J. Randall, A. Scherag, Anna A. E. Vinkhuyzen, H. Westra, T. Winkler, T. Workalemahu, J. Zhao, D. Absher, E. Albrecht, Denise Anderson, J. Baron, M. Beekman, A. Demirkan, G. Ehret, B. Feenstra, M. Feitosa, K. Fischer, Ross M. Fraser, A. Goel, Jian Gong, A. Justice, S. Kanoni, M. Kleber, K. Kristiansson, U. Lim, Vaneet Lotay, J. Lui, M. Mangino, I. Leach, C. Medina-Gomez, M. Nalls, D. Nyholt, Cameron D. Palmer, D. Pasko, S. Pechlivanis, I. Prokopenko, J. Ried, S. Ripke, D. Shungin, A. Stančáková, R. Strawbridge, Y. Sung, Toshiko Tanaka, A. Teumer, S. Trompet, S. W. van der Laan, J. van Setten, Jana V. van Vliet-Ostaptchouk, Zhaoming Wang, L. Yengo, Weihua Zhang, U. Afzal, J. Ärnlöv, Gillian M. Arscott, S. Bandinelli, Amy Barrett, C. Bellis, A. Bennett, C. Berne, M. Blüher, J. Bolton, Y. Böttcher, H. Boyd, M. Bruinenberg, B. Buckley, S. Buyske, I. H. Caspersen, P. Chines, R. Clarke, S. Claudi‐boehm, M. Cooper, E. W. Daw, P. D. de Jong, J. Deelen, G. Delgado, J. Denny, R. Dhonukshe-Rutten, M. Dimitriou, A. Doney, M. Dörr, N. Eklund, Elodie Eury, L. Folkersen, M. Garcia, F. Geller, V. Giedraitis, A. Go, H. Grallert, T. Grammer, J. Grässler, H. Grönberg, L. D. de Groot, C. Groves, J. Haessler, P. Hall, T. Haller, G. Hallmans, A. Hannemann, C. Hartman, M. Hassinen, C. Hayward, N. Heard-Costa, Q. Helmer, G. Hemani, A. Henders, H. Hillege, M. Hlatky, W. Hoffmann, P. Hoffmann, O. Holmen, J. Houwing-Duistermaat, T. Illig, A. Isaacs, A. James, Janina M. Jeff, B. Johansen, Å. Johansson, J. Jolley, Thorhildur Juliusdottir, J. Junttila, A. Kho, L. Kinnunen, N. Klopp, T. Kocher, W. Kratzer, P. Lichtner, L. Lind, J. Lindström, S. Lobbens, M. Lorentzon, Yingchang Lu, V. Lyssenko, P. Magnusson, A. Mahajan, M. Maillard, W. McArdle, C. McKenzie, S. McLachlan, P. McLaren, C. Menni, S. Merger, L. Milani, A. Moayyeri, K. Monda, M. Morken, G. Müller, M. Müller-Nurasyid, A. Musk, Narisu Narisu, M. Nauck, I. Nolte, M. Nöthen, Laticia Oozageer, S. Pilz, N. W. Rayner, Frida Renstrom, N. Robertson, L. Rose, R. Roussel, S. Sanna, H. Scharnagl, S. Scholtens, F. Schumacher, H. Schunkert, R. Scott, J. Sehmi, T. Seufferlein, Jianxin Shi, K. Silventoinen, J. Smit, A. Smith, Joanna Smolonska, A. Stanton, K. Stirrups, D. Stott, H. Stringham, J. Sundström, M. Swertz, A. Syvänen, B. Tayo, G. Thorleifsson, J. Tyrer, S. V. van Dijk, N. V. van Schoor, Nathalie van der Velde, D. van Heemst, F. V. van Oort, S. Vermeulen, N. Verweij, J. Vonk, L. Waite, M. Waldenberger, R. Wennauer, L. Wilkens, C. Willenborg, T. Wilsgaard, M. Wojczynski, A. Wong, A. Wright, Qunyuan Zhang, D. Arveiler, S. Bakker, J. Beilby, R. Bergman, S. Bergmann, R. Biffar, J. Blangero, D. Boomsma, S. Bornstein, P. Bovet, P. Brambilla, Morris J. Brown, H. Campbell, M. Caulfield, A. Chakravarti, R. Collins, F. Collins, D. Crawford, L. Cupples, J. Danesh, U. de Faire, H. D. den Ruijter, R. Erbel, J. Erdmann, J. Eriksson, M. Farrall, E. Ferrannini, J. Ferrières, I. Ford, N. Forouhi, T. Forrester, R. Gansevoort, P. Gejman, C. Gieger, A. Golay, O. Gottesman, V. Gudnason, U. Gyllensten, D. Haas, A. Hall, T. Harris, A. Hattersley, A. Heath, C. Hengstenberg, A. Hicks, L. Hindorff, A. Hingorani, A. Hofman, G. K. Hovingh, S. Humphries, S. Hunt, E. Hypponen, K. Jacobs, M. Jarvelin, P. Jousilahti, A. Jula, J. Kaprio, J. Kastelein, M. Kayser, F. Kee, S. Keinanen-Kiukaanniemi, L. Kiemeney, J. Kooner, C. Kooperberg, S. Koskinen, P. Kovacs, A. Kraja, M. Kumari, J. Kuusisto, T. Lakka, C. Langenberg, L. Le Marchand, T. Lehtimäki, S. Lupoli, P. Madden, S. Männistö, P. Manunta, A. Marette, T. Matise, B. McKnight, T. Meitinger, F. Moll, G. Montgomery, A. Morris, A. Morris, J. Murray, M. Nelis, C. Ohlsson, A. Oldehinkel, K. Ong, W. Ouwehand, G. Pasterkamp, A. Peters, P. Pramstaller, J. Price, L. Qi, O. Raitakari, T. Rankinen, D. Rao, T. Rice, M. Ritchie, I. Rudan, V. Salomaa, N. Samani, J. Saramies, M. Sarzynski, P. Schwarz, S. Sebert, P. Sever, A. Shuldiner, J. Sinisalo, V. Steinthorsdottir, R. Stolk, J. Tardif, A. Tönjes, A. Tremblay, E. Tremoli, J. Virtamo, M. Vohl, P. Amouyel, F. Asselbergs, T. Assimes, M. Bochud, B. Boehm, E. Boerwinkle, E. Bottinger, C. Bouchard, S. Cauchi, J. Chambers, S. Chanock, R. Cooper, P. D. de Bakker, G. Dedoussis, L. Ferrucci, P. Franks, P. Froguel, L. Groop, C. Haiman, A. Hamsten, M. Hayes, J. Hui, D. Hunter, K. Hveem, J. Jukema, R. Kaplan, M. Kivimaki, D. Kuh, M. Laakso, Yongmei Liu, N. Martin, W. März, M. Melbye, S. Moebus, P. Munroe, I. Njølstad, B. Oostra, C. Palmer, N. Pedersen, M. Perola, L. Pérusse, U. Peters, J. Powell, C. Power, T. Quertermous, R. Rauramaa, E. Reinmaa, P. Ridker, F. Rivadeneira, J. Rotter, T. Saaristo, D. Saleheen, D. Schlessinger, P. Slagboom, H. Snieder, T. Spector, K. Strauch, M. Stumvoll, J. Tuomilehto, M. Uusitupa, P. van der Harst, H. Völzke, M. Walker, N. Wareham, H. Watkins, H. Wichmann, James F. Wilson, P. Zanen, P. Deloukas, I. Heid, C. Lindgren, K. Mohlke, Elizabeth K. Speliotes, U. Thorsteinsdóttir, I. Barroso, C. Fox, K. North, D. Strachan, J. Beckmann, S. Berndt, M. Boehnke, I. Borecki, M. McCarthy, A. Metspalu, K. Stefánsson, A. Uitterlinden, C. V. van Duijn, L. Franke, C. Willer, A. Price, G. Lettre, R. Loos, M. Weedon, E. Ingelsson, J. O’Connell, G. Abecasis, D. Chasman, M. Goddard, P. Visscher, J. Hirschhorn, T. Frayling +444 moresemanticscholar +1 more sourceIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourcePubertal Development and Prepubertal Height and Weight Jointly Predict Young Adult Height and Body Mass Index in a Prospective Study in South Africa
Journal of NutriLife, 2016 Background: Height and adiposity track over childhood, but few studies, to our knowledge, have longitudinally examined the mediating relation of the timing and progression of puberty.A. Stein, E. Lundeen, R. Martorell, P. Suchdev, N. Mehta, L. Richter, S. Norris +6 moresemanticscholar +1 more sourceChanges in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background
Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers' Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen +11 morewiley +1 more sourceAge‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives
We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker +3 morewiley +1 more sourceAdult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis
International Journal of Epidemiology, 2015 Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis.E. Nüesch, C. Dale, T. Palmer, Jon White, B. Keating, Erik P A van Iperen, A. Goel, S. Padmanabhan, F. Asselbergs, W. Verschuren, C. Wijmenga, Y. T. van der Schouw, N. Onland-Moret, L. Lange, G. Hovingh, S. Sivapalaratnam, R. Morris, P. Whincup, Goya S Wannamethe, Tom R. Gaunt, S. Ebrahim, L. Steel, N. Nair, A. Reiner, C. Kooperberg, James F. Wilson, J. Bolton, S. McLachlan, J. Price, M. Strachan, C. Robertson, M. Kleber, G. Delgado, W. März, O. Melander, A. Dominiczak, M. Farrall, H. Watkins, M. Leusink, A. H. Maitland‐van der Zee, M. D. de Groot, F. Dudbridge, A. Hingorani, Y. Ben-Shlomo, D. Lawlor, A. Amuzu, M. Caufield, A. Cavadino, J. Cooper, T. Davies, F. Drenos, J. Engmann, C. Finan, C. Giambartolomei, R. Hardy, S. Humphries, E. Hypponen, M. Kivimaki, D. Kuh, M. Kumari, K. Ong, V. Plagnol, C. Power, M. Richards, S. Shah, T. Shah, R. Sofat, P. Talmud, N. Wareham, H. Warren, J. Whittaker, A. Wong, D. Zabaneh, G. Davey Smith, J. Wells, D. Leon, M. Holmes, J. Casas +77 moresemanticscholar +1 more source
