Results 51 to 60 of about 986,800 (264)

Breast, colon, and prostate screening in the adult population of Croatia: does rural origin matter? [PDF]

, 2007
INTRODUCTION: The aim of this study was to investigate the utilization of breast, colon and prostate cancer screening in the adult Croatian population in a period without national cancer screening programs, with a special interest in respondents' rural ...
Kern, Josipa, Kolčić, Ivana, Polašek, Ozren, Strnad, Marija, Vončina, Luka, Vuletić, Silvije   +5 more
core  

Contradictions in adult education structures and policies in Austria: their interrelation with the professional development of educators [PDF]

, 2011
This article analyses the structural influences on the professional development of adult educators and their relation to education policy using Austria as a fairly average example of the diversity in European adult education.
Lassnigg, Lorenz
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Prevalence of high 10-year cardiovascular risk among the general population in Malaysia and the associated factors: a nationwide community-based study in 2023

BMC Public Health
Background Cardiovascular disease (CVD) is a leading cause of death in Malaysia. Knowing the current distribution of 10-year CVD risk among the general population is essential for health planning and targeted interventions. Hence, we aim to determine the
Kim Sui Wan, Muhammad Fadhli Mohd Yusoff, Halizah Mat Rifin, Wah Kheong Chan, Nazirah Alias, Sin Wan Tham, Mohd Azmi Bin Suliman, Tania Gayle Robert Lourdes, Thamil Arasu Saminathan, Ping Foo Wong, Masni Mohamad, Nurain Mohd Noor, Lee-Ling Lim, Feisul Mustapha, Noor Ani Ahmad   +14 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Global Employment Trends for Youth: October 2008 [PDF]

, 2008
[Excerpt] An intensified focus on youth at the international level in recent years has brought a greater understanding of youth labour markets and led to development of a growing number of national action plans for youth employment as well as other more ...
International Labour Office
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Appointment waiting times and education level influence the quality of bowel preparation in adult patients undergoing colonoscopy

BMC Gastroenterology, 2011
Background Risk factors for poor bowel preparation are recognized to be independent of the type of bowel preparation method used. Patient and administrative factors influencing bowel preparation are known to vary in different healthcare systems.
Goh Khean-Lee, Manikam Jeeta, Saravanan Arjunan, Chan Wah-Kheong, Mahadeva Sanjiv   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Trajectories of Objectively Measured Physical Activity among Secondary Students in Canada in the Context of a Province-Wide Physical Education Policy: A Longitudinal Analysis

Journal of Obesity, 2014
Lower levels of physical activity are associated with childhood obesity. School physical education (PE) policies have been identified as critical to improve child and adolescent physical activity levels but there has been little evaluation of such ...
Erin Hobin, Jannice So, Laura Rosella, Melisa Comte, Steve Manske, Jonathan McGavock   +5 more
doaj   +1 more source