Results 71 to 80 of about 986,800 (264)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
The Nonequivalence of High School Equivalents [PDF]
This paper analyzes the causes and consequences of the growing proportion of high-school-certified persons who achieve that status by exam certification rather than through high school graduation.
James J. Heckman, Stephen V. Cameron
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Preparing Low-Skilled Workers for the Jobs of Tomorrow [PDF]
, 2008 Identifies ways for state policies to leverage technology-based economic development by preparing low-skilled workers for middle-skill, technical jobs in the fields of science, technology, engineering, and math (STEM).
Kenneth E. Poole
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Does Gender Inequality Reduce Growth and Development? Evidence from Cross-Country Regressions [PDF]
, 2000 Using cross-country and panel regressions, this paper investigates to what extent gender inequality in education and employment may reduce growth and development.
Klasen, Stephan
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Economic impact of training and education in basic skills: summary of evidence (BIS research paper no.6) [PDF]
, 2009 This paper summarises recent quantitative evidence on the economic returns to having or improving literacy and numeracy skills. The summary includes evidence on earnings and employment, and distinguishes between returns to having basic skills whenever ...
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Making their Way: Helping Kentucky's Immigrant Youth Successfully Transition into Adulthood [PDF]
, 2008 All youth in Kentucky need high quality educational experiences to become successful adults. Children must have access to educational opportunities at every stage of development, from early child care and preschool to post-secondary education or ...
Jenessa Bryan, Tara Grieshop-Goodwin
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Fibre intake among the Belgian population by sex-age and sex-education groups and its association with BMI and waist circumference [PDF]
, 2011 The objectives of the present study were to assess total dietary fibre intake and the main contributors to fibre intake in the Belgian population by sex-age and sex-education groups and to investigate its relationship with BMI and waist circumference (WC)
Alaimo +21 more
core +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source