Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Development of Temporal Memory for Complex Events. [PDF]
Dev SciFrisoni M +4 more
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Is Religious Coping a Protective Factor, and for Whom? A Moderation and Subgroup Analysis on Loneliness and Suicide Attempts Among LGBTQ+ Adults Raised as Latter-Day Saints. [PDF]
Suicide Life Threat BehavKim S +3 more
europepmc +1 more source
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis.
The Lancet, 1992 D. Celermajer +7 more
semanticscholar +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Computer-Assisted Performance-Based Assessment for Mental Health: A Scoping Review. [PDF]
Psych JLi H, Li S.
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The indicator (key figure) presented here is part of the Diabetes Surveillance indicator set (research project at the Robert Koch Institute 2015 – 2024) with a total of 40 defined indicators or indicator groups. In addition to the indicator results, the methodological approach and the data source are described and the data are provided in aggregated ...
openaire +2 more sources
Gait speed and survival in older adults.
Journal of the American Medical Association (JAMA), 2011 S. Studenski +18 more
semanticscholar +1 more source