Results 211 to 220 of about 6,534,996 (345)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Global and tract-specific differences between younger and older adults in DTI measures of white matter integrity. [PDF]

Front Aging Neurosci
Matijevic S, Ryan L.
europepmc   +1 more source

X-RAY EXPERIMENTS WITH MOLGULA MANHATTENSIS: ADULT SENSITIVITY AND INDUCED ZYGOTIC LETHALITY

, 1957
Daniel S. Grosch, Zoe H. Smith
openalex   +2 more sources

MORPHOGENETIC STUDIES OF THE RABBIT. XVII. DISPROPORTIONATE ADULT SIZE INDUCED BY THE DA GENE [PDF]

, 1957
P. B. Sawin, D. D. Crary
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The Otago Exercise Program's effect on fall prevention: a systematic review and meta-analysis. [PDF]

Front Public Health
Wang C, Kim SM.
europepmc   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Postural sway variability in young adults presents higher complexity during morning compared to evening hours while in older adults remains the same. [PDF]

Exp Brain Res
Mylonas V, Grioriadis S, Chalitsios C, Stergiou N, Nikodelis T.   +4 more
europepmc   +1 more source

Evaluation of the Level of Properdin in Normal Adult Humans and in Certain Disease States

, 1958
Victor D. Newcomer, Earl G. McNall, Carlyn Halde, Edwin T. Wright, Thomas H. Sternberg   +4 more
openalex   +1 more source

The origin and growth of brain cells in the adult body [PDF]

, 1896
Howard Ayers
openalex   +1 more source