Results 241 to 250 of about 6,150,027 (314)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Addressing Older Adults' Sexual Health Needs in Regional Primary Care: A Qualitative Study of Barriers and Enablers. [PDF]

Aust J Rural Health
Bourchier L, Ware L, Temple-Smith M, Hocking JS, Tomnay J, Malta S.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Cognitive factors associated with willingness to receive three important vaccines among older adults: A protection motivation theory perspective. [PDF]

Hum Vaccin Immunother
Peng X, Huang R, Walker AN, Zhang L, Miao Y, Yu Q, Li L.   +6 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Digital Resources and Social Connectedness Among Ethnic Minority Older Adults: Systematic Review and Meta-Analysis. [PDF]

JMIR Aging
Amoah PA, Ameyaw EK, Bhowmik MK, Adotey PN, Donkor A.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Associations between community-based aged care services and subjective well-being among older adults in China: the mediating roles of self-rated and mental health. [PDF]

PLoS One
Wang Y, Bai X, Zhao H.
europepmc   +1 more source

Trends and Disparities in Obesity-Related Mortality Among U.S. Adults: A CDC WONDER Analysis (1968-2025). [PDF]

Obes Sci Pract
Ahmed F, Ahmed H, Ishtiaq A, Gohar N, Goel A, Waheed A, Rehman Mirza T, Bin Tahir H, Saleemi F, Mushtaq Hashmi T, Ali R, Jain H, Ahmed M, Deshmukh F, Bakr M, Patel S, Hossain M, Haider Cheema A.   +17 more
europepmc   +1 more source