Results 61 to 70 of about 5,977,231 (321)

Towards Inclusive Design for Privacy and Security Perspectives from an Aging Society [PDF]

arXiv, 2020
Over the past few years, older adults in Singapore have been massively connecting to the Internet using Smartphone. However due to the ever-changing nature of Technology and Cybersecurity landscape, an older adult's limited technical and Privacy and Security (P & S) knowledge, experience and declining cognitive and physical abilities puts them at ...
arxiv  

Increased prevalence of sleep-disordered breathing in adults.

American Journal of Epidemiology, 2013
Sleep-disordered breathing is a common disorder with a range of harmful sequelae. Obesity is a strong causal factor for sleep-disordered breathing, and because of the ongoing obesity epidemic, previous estimates of sleep-disordered breathing prevalence ...
P. Peppard, T. Young, J. Barnet, M. Palta, E. Hagen, K. Hla   +5 more
semanticscholar   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Gait speed and survival in older adults.

Journal of the American Medical Association (JAMA), 2011
CONTEXT Survival estimates help individualize goals of care for geriatric patients, but life tables fail to account for the great variability in survival.
S. Studenski, S. Perera, K. Patel, C. Rosano, K. Faulkner, M. Inzitari, J. Brach, J. Chandler, Peggy Cawthon, E. B. Connor, M. Nevitt, M. Visser, S. Kritchevsky, Stefania Badinelli, T. Harris, A. Newman, J. Cauley, L. Ferrucci, J. Guralnik   +18 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Parents’ Experience in an Italian NICU Implementing NIDCAP-Based Care: A Qualitative Study

Children, 2022
Background: The birth of a preterm infant and his/her immediate admittance to the Neonatal Intensive Care Unit (NICU) are sudden, unexpected, stressful and painful events for parents.
Natascia Bertoncelli, Licia Lugli, Luca Bedetti, Laura Lucaccioni, Arianna Bianchini, Alessandra Boncompagni, Federica Cipolli, Anna Cinzia Cosimo, Giovanna Cuomo, Michela Di Giuseppe, Tamara Lelli, Veronica Muzzi, Martina Paglia, Lucia Pezzuti, Claudia Sabbioni, Francesca Salzone, Maria Cristina Sorgente, Fabrizio Ferrari, Alberto Berardi   +18 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016

MMWR. Morbidity and mortality weekly report, 2018
Chronic pain, one of the most common reasons adults seek medical care (1), has been linked to restrictions in mobility and daily activities (2,3), dependence on opioids (4), anxiety and depression (2), and poor perceived health or reduced quality of life
James M. Dahlhamer, J. Lucas, C. Zelaya, R. Nahin, S. Mackey, L. DeBar, Robert W Kerns, M. Von Korff, L. Porter, C. Helmick   +9 more
semanticscholar   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source