Results 61 to 70 of about 10,055,911 (359)

Bleeding assessment in a large cohort of patients with Osteogenesis Imperfecta

Orphanet Journal of Rare Diseases
Background Osteogenesis Imperfecta (OI) is characterised by bone fragility. Among several features, easy bruising and multiple case reports on haemorrhagic events have been reported.
Koert Gooijer, Gabriëla Heidsieck, Arjan Harsevoort, Daniëlle Bout, Guus Janus, Anton Franken   +5 more
doaj   +1 more source

Factors involved in correct analysis of intracardiac electrograms captured by Medtronic Inc. pacemakers during tachycardias

Journal of Arrhythmia, 2013
Background: To thoroughly investigate the diagnostic information obtained by pacemakers, it is important that the stored intracardiac electrograms (EGMs) are analyzed.
Masaru Takagaki, ME, Shigeru Ikeguchi, MD, Tomoyuki Yamada, MD, Kazuhiko Katsuyama, MD, Yuzo Takeuchi, MD, Shinsaku Takeda, MD, Yoshitaka Kawata, MD, Takeshi Harita, MD, Akio Morii, ME, Hiroaki Nanba, ME, Shinichi Hasegawa, ME, Shinichiro Sukenari, ME, Hiroshi Terada, ME   +12 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Schizophrenia in older adults [PDF]

, 2011
Although the number of persons over the age of 55 with schizophrenia is expected to double over the next 20 years, the research data on older people with schizophrenia is limited.
American Psychiatric Association, Bleuler, Bleuler, Bridge, Collier, Collier, Collier, Elizabeth Collier, Jeanne M. Sorrell, Palmer, Roth, Snowden, World Health Organization   +12 more
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Health System Performance for the High-Need Patient: A Look at Access to Care and Patient Care Experiences [PDF]

, 2016
Achieving a high-performing health system will require improving outcomes and reducing costs for high-need, high-cost patients—those who use the most health care services and account for a disproportionately large share of health care spending.
Claudia A. Salzberg, David C. Radley, Douglas McCarthy, Gerard F. Anderson, Melinda K. Abrams, Susan L. Hayes, Tanya Shah   +6 more
core  

Relationship between neighborhood walkability and older adults' physical activity : results from the Belgian Environmental Physical Activity Study in Seniors (BEPAS Seniors) [PDF]

, 2014
Background: Adequate knowledge on environmental correlates of physical activity (PA) in older adults is needed to develop effective health promotion initiatives.
De Bourdeaudhuij, Ilse, Deforche, Benedicte, Van Cauwenberg, Jelle, Van de Weghe, Nico, Van Dyck, Delfien, Van Holle, Veerle   +5 more
core   +2 more sources

Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016

MMWR. Morbidity and mortality weekly report, 2018
Chronic pain, one of the most common reasons adults seek medical care (1), has been linked to restrictions in mobility and daily activities (2,3), dependence on opioids (4), anxiety and depression (2), and poor perceived health or reduced quality of life
James M. Dahlhamer, J. Lucas, C. Zelaya, R. Nahin, S. Mackey, L. DeBar, Robert W Kerns, M. Von Korff, L. Porter, C. Helmick   +9 more
semanticscholar   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Symptoms and symptom clusters in patients with hepatocellular carcinoma and commonly used instruments: An integrated review

International Journal of Nursing Sciences
Objective: This study aimed to synthesize the available knowledge of identifying hepatocellular carcinoma (HCC) symptoms and symptom clusters in patients with HCC and instruments used for these assessments to maximize symptom management.
Thitiporn Pathomjaruwat, Yaowarat Matchim, Jane M. Armer   +2 more
doaj   +1 more source