Results 161 to 170 of about 4,825,638 (305)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

One-year survival after critical care as a decision basis for advance care directives in general medicine: Real word data analysis of 149,144 patients. [PDF]

PLoS One
Unger C, Werner F, Engel B, Kühlein T, Schulz C, Kümpel C, Gorkotte J, Hueber S.   +7 more
europepmc   +1 more source

Doctors' perspectives on adhering to advance care directives when making medical decisions for patients: an Australian interview study. [PDF]

BMJ Open, 2019
Moore N, Detering KM, Low T, Nolte L, Fraser S, Sellars M.   +5 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Increasing the uptake of advance care directives through staff education and one-on-one support for people facing end-of-life. [PDF]

BMJ Open Qual
Kinsman LD, Mooney G, Whiteford G, Lower T, Hobbs M, Morris B, Bartlett K, Jacob A, Curley D.   +8 more
europepmc   +1 more source

Informed Consent and Advance Care Directives: Cornerstones and Outstanding Issues in the Newly Enacted Italian Legislation. [PDF]

Linacre Q, 2019
Montanari Vergallo G, Spagnolo AG.
europepmc   +1 more source

Advance Directives: Attitudes of Primary Care Providers

, 2012
Thesis (M.Nurs.), College of Nursing, Washington State UniversityAdvance directives are the expression of a patient's preferences regarding the use of life-sustaining treatments made while they still possess decision making capacity.
Strom, Patricia L.
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Acknowledgement and use of advance care directives and goals of care by emergency department staff: a mixed method post intervention study. [PDF]

BMC Palliat Care
Osman AD, Howell J, Yeoh M, Lam L, Jones D, Braitberg G.   +5 more
europepmc   +1 more source