Results 31 to 40 of about 7,455 (267)

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Correlation between vegetation indices obtained by rpa and grain yield

Conexões: Ciência e Tecnologia
The objective of this study was to evaluate the correlations between vegetation indices (VI), obtained by RGB camera on flights of Remotely piloted aircraft System (RPA), with yield maps of agricultural crops.
Helton Aparecido Rosa, Jerry Adriani Johann, Willyan Ronaldo Becker, João Felipe Cesar Silveira, Idelvan Bonadiman Blanco   +4 more
doaj   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

The Clearing Timescale for Infrared-selected Star Clusters in M83 with HST

The Astrophysical Journal Letters
We present an analysis of Hubble Space Telescope data from Wide Field Camera 3 (WFC3)/Ultraviolet Imaging Spectrometer, WFC3/IR, and the Advanced Camera for Surveys, investigating the young stellar cluster (YSC) population in the face-on spiral galaxy ...
Suyash Deshmukh, Sean T. Linden, Daniela Calzetti, Angela Adamo, Matteo Messa, Kathryn Grasha, Elena Sabbi, Linda Smith, Kelsey E. Johnson   +8 more
doaj   +1 more source

The Absolute Age of M92

The Astronomical Journal, 2023
The absolute age of a simple stellar population is of fundamental interest for a wide range of applications but is difficult to measure in practice, as it requires an understanding of the uncertainties in a variety of stellar evolution processes as well ...
Jiaqi (Martin) Ying, Brian Chaboyer, Emily M. Boudreaux, Catherine Slaughter, Michael Boylan-Kolchin, Daniel Weisz   +5 more
doaj   +1 more source

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

Arthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah, Alexis Castellanos, Yen Chen, John Piette, Amy Bucher, Susan Murphy   +5 more
wiley   +1 more source

The Proper Motion of Draco II with HST Using Multiple Reference Frames and Methodologies

The Astrophysical Journal
We present proper motion (PM) measurements for Draco II, an ultrafaint dwarf satellite of the Milky Way. These PMs are measured using two epochs of Hubble Space Telescope (HST)/Advanced Camera for Surveys imaging separated by a 7 yr temporal baseline ...
Jack T. Warfield, Kevin A. McKinnon, Sangmo Tony Sohn, Nitya Kallivayalil, Alessandro Savino, Roeland P. van der Marel, Andrew B. Pace, Christopher T. Garling, Niusha Ahvazi, Paul Bennet, Roger E. Cohen, Matteo Correnti, Mark A. Fardal, Kristen. B. W. McQuinn, Max J. B. Newman, Eduardo Vitral   +15 more
doaj   +1 more source