Results 51 to 60 of about 120,351 (278)

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Search for the elusive optical counterpart of PSR J0537–6910 with the HST Advanced Camera for Surveys [PDF]

Astronomy & Astrophysics, 2005
We present the results of deep, high-resolution, multi-band optical observations of the field of the young (~ 5,000 yrs) 16 ms X-ray pulsar PSR J0537$-$6910 performed with the Advanced Camera for Surveys (ACS) aboard the Hubble Space Telescope (HST). Although a few new potential counterparts have been detected within or close to the revised Chandra X ...
George G. Pavlov, Oleg Kargaltsev, G. Iannicola, Leisa K. Townsley, L. Pulone, R. P. Mignani   +5 more
openaire   +3 more sources

Panchromatic Hubble Andromeda Treasury IX: A Photometric Survey of Planetary Nebulae in M31 [PDF]

, 2014
We search Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) and Wide Field Camera 3 (WFC3) broadband imaging data from the Panchromatic Hubble Andromeda Treasury (PHAT) survey to identify detections of cataloged planetary nebulae (PNe).
Balick, Bruce, Caldwell, Nelson, Dalcanton, Julianne J., Fouesneau, Morgan, Girardi, Leo, Gordon, Karl, Kalirai, Jason, Rosenfield, Phil, Seth, Anil, Veyette, Mark J., Williams, Benjamin F.   +10 more
core   +2 more sources

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

Molecular Oncology, Volume 19, Issue 4, Page 1092-1116, April 2025.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, Maria J Barrero, Diego Megías, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez‐Dominguez, Sara Monzón, Isabel Cuesta, Laura Sánchez, Rodrigo Barderas, Jesús García‐Donas, Alberto Martín, Ignacio Pérez de Castro   +17 more
wiley   +1 more source

HST Proper Motion of Andromeda III. Another Satellite Coorbiting the M31 Satellite Plane

The Astrophysical Journal
We measure the absolute proper motion of Andromeda III (And III) using Advanced Camera for Surveys/Wide Field Channel and WFPC2 exposures spanning an unprecedented 22 yr time baseline.
Dana I. Casetti-Dinescu, Marcel S. Pawlowski, Terrence M. Girard, Kosuke Jamie Kanehisa, Alexander Petroski, Max Martone, Vera Kozhurina-Platais, Imants Platais   +7 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Resolving a Candidate Dual Active Galactic Nucleus with ∼100 pc Separation in MCG-03-34-64

The Astrophysical Journal
We report the serendipitous multiwavelength discovery of a candidate dual black hole system with a separation of ∼100 pc, in the gas-rich luminous infrared galaxy MCG-03-34-64 ( z = 0.016).
Anna Trindade Falcão, T. J. Turner, S. B. Kraemer, J. Reeves, V. Braito, H. R. Schmitt, L. Feuillet   +6 more
doaj   +1 more source

Resolved SPLASH Chemodynamics in Andromeda’s PHAT Stellar Halo and Disk: On the Nature of the Inner Halo along the Major Axis

The Astronomical Journal, 2023
Stellar kinematics and metallicity are key to exploring formation scenarios for galactic disks and halos. In this work, we characterized the relationship between kinematics and photometric metallicity along the line of sight to M31's disk.
Ivanna Escala, Amanda C. N. Quirk, Puragra Guhathakurta, Karoline M. Gilbert, J. Leigh Wojno, Lara Cullinane, Benjamin F. Williams, Julianne Dalcanton   +7 more
doaj   +1 more source

Variable Star Candidates in an ACS Field of M31

, 2005
A search for variable stars is performed using two epochs of Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) imaging data for a 9.28 square arcminute portion of M31.
Ansari R., Benjamin F. Williams, Castellani V., de Laverny P., Filippenko A. V., Garcia J. R., Massey P., Rector T. A., Romano D., Rosino L., Sharov A. S.   +10 more
core   +1 more source

Protein crystallization and structure determination at room temperature in the CrystalChip

FEBS Open Bio, Volume 15, Issue 4, Page 532-541, April 2025.
This protocol describes the implementation of a simple and user‐friendly microfluidic device called CrystalChip that allows the production of crystals by the counter‐diffusion method and their in situ analysis by serial crystallography. As an illustration, it is applied to determine the 3D structure of three proteins from data collected at room ...
Petr Pachl, Léna Coudray, Romain Vincent, Léa Nilles, Hélène Scheer, Christophe Ritzenthaler, Adéla Fejfarová, Pavlína Řezáčová, Sylvain Engilberge, Claude Sauter   +9 more
wiley   +1 more source