Results 101 to 110 of about 2,067,406 (314)

Vermonters’ Opinions on Low-Dose CT Lung Cancer Screening [PDF]

, 2015
Introduction: Lung cancer is the number one cause of cancer death among men and women in Vermont and the United States. Smoking increases the risk of lung cancer—nearly 90% of lung cancer is due to smoking.
Albertson, Benjamin, Bennett, Eric, Chiang, Homer, Kaminsky, David, Keller, Erin, Lantz, Katherine, Ma, Melanie, Mallory, Sharon, Ryan, Rebecca   +8 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Practice Patterns of Palliative Radiotherapy for Advanced Cancer at a Large Institute in Saudi Arabia

Palliative Medicine Reports
Background and Aims: Palliative radiotherapy practice patterns have been reported to vary widely, with a notable underutilization of single fraction treatment schedules.
Wsam Ghandourh, Zaheeda Mulla, Belal Sharaf, Elham Ghabashi, Anan Bamakhrama   +4 more
doaj   +1 more source

Patient and clinician experience of a serious illness conversation guide in oncology: A descriptive analysis

Cancer Medicine, 2020
Background/objective Oncology guidelines recommend earlier communication with patients about prognosis and goals‐of‐care in serious illness. However, current evidence leaves gaps in our understanding of the experience of these conversations.
Joanna Paladino, Luca Koritsanszky, Lauren Nisotel, Bridget A. Neville, Kate Miller, Justin Sanders, Evan Benjamin, Erik Fromme, Susan Block, Rachelle Bernacki   +9 more
doaj   +1 more source

3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells [PDF]

, 2017
Immunotherapy efficacy relies on the crosstalk within the tumor microenvironment between cancer and dendritic cells (DCs) resulting in the induction of a potent and effective antitumor response.
Bentivegna, Enrico, Bertani, Francesca Romana, Buoncervello, Maria, Businaro, Luca, Canini, Irene, De Ninno, Adele, Falchi, Mario, Fragale, Alessandra, Gabriele, Lucia, Gerardino, Annamaria, Martinelli, Eugenio, Mencattini, Arianna, Molfetta, Rosa, Natale, Corrado, Paolini, Rossella, Parlato, Stefania, Roccazzello, Lorenzo, Romagnoli, Giulia, Salerno, Debora, Toschi, Elena   +19 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Relevance of Patient-Reported Outcome Measures in Patients with Cancer: Detection of Underrated Psychological Distress of Palliative Care Patients in an Outpatient Setting

Palliative Medicine Reports
Background: The overall level of physical and psychological symptom burden of advanced cancer patients (ACP) in an outpatient setting is notoriously difficult to assess.
Madeleine Fink, Sandy Müller, Eva Warnecke, Jörg Hense, Martin Schuler, Martin Teufel, Maria Rosa Salvador Comino, Mitra Tewes   +7 more
doaj   +1 more source

Individualized quality of life, standardized quality of life, and distress in patients undergoing a phase I trial of the novel therapeutic Reolysin (reovirus)

Health and Quality of Life Outcomes, 2005
Background The purpose of this study was to evaluate the individualized and standardized quality of life (QL) and psychological distress of patients participating in a Phase I trial of the novel therapeutic reovirus (Reolysin).
Bultz Barry D, Carlson Linda E, Morris Donald G   +2 more
doaj   +1 more source

Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma [PDF]

, 2015
The prevalence of global obesity is increasing. Obesity is associated with general cancer-related morbidity and mortality and is a known risk factor for development of specific cancers.
Alfraidi, Albandri, Alshaker, Heba, Muhammad, Aun, Pchejetski, Dmitri, Sacco, Keith, Winkler, Mathias   +5 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source