Results 101 to 110 of about 2,075,210 (312)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The mediating effect of resourcefulness between self-management efficacy and cancer-related fatigue in advanced cancer patients (智谋在晚期癌症患者自我管理效能与癌因性疲乏间的中介效应分析)

中西医结合护理
Objective To explore the mechanism of resourcefulness in self-management efficacy and cancer-related fatigue in patients with advanced cancer, so as to provide reference for improving the fatigue level.
YIN Min (殷敏), GAN Xia (干霞), FENG Yanru (冯雁茹)   +2 more
doaj   +1 more source

A grounded theory approach to physical activity and advanced cancer:a qualitative study protocol [PDF]

, 2015
Background: Physical activity has demonstrated benefits in cancer-related fatigue and physical functioning in early-stage cancer patients; however, the role of physical activity at the end stage of cancer has not been established. To challenge positivist–
Brearley, Sarah Grace, Lowe, Sonya S., Milligan, Christine, Watanabe, Sharon M.   +3 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A Perfect Blend of ‘Palliative Heart’ and ‘Oncology Brain’ in an Advanced Cancer Patient

NMO Journal
Cancer of the oesophagus is the 9th-most common cancer worldwide and the 5th-most common malignancy in India amongst both genders. It usually presents in an advanced stage, and approximately half of them have metastatic disease at the time of ...
Mrinalini Verma, Puja Kumari, Divya Kukreja   +2 more
doaj   +1 more source

Urothelial bladder carcinoma metastasizing to the eye: a systematic review and case report [PDF]

, 2019
The eye is a rare site for disseminated malignancies; nevertheless, several tumors may metastasize to ocular structures. Few cases of urothelial and bladder cancer with eye involvement have been described in the literature thus far.
Brunelli, Matteo, Coppola, Giulia, Coppola, Luigi, D'Andrea, Mario Rosario, de Santis, Elena, Di Raimo, Tania, Giordano, Guido, Manfrin, Erminia, Olivieri, Nunzio, Pancione, Massimo, Parcesepe, Pietro, Remo, Andrea, Scarpa, Aldo   +12 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Living with advanced cancer: Rich Pictures as a means for health care providers to explore the experiences of advanced cancer patients

Cancer Medicine, 2019
Background To provide holistic care to patients with advanced cancer, health care professionals need to gain insight in patients’ experiences across the different domains of health.
Zarah M. Bood, Michael Scherer‐Rath, Mirjam A. G. Sprangers, Liesbeth Timmermans, Ellen vanWolde, Sayra M. Cristancho, Fenna Heyning, Silvia Russel, Hanneke W. M. vanLaarhoven, Esther Helmich   +9 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Which interval is most crucial to presentation and survival in gastroesophageal cancer: a systematic review [PDF]

, 2017
Aim: The aim of this study was to identify the most crucial interval to encourage earlier diagnosis in with gastroesophageal cancer and to identify potential factors effecting this interval.
Khulusi, Sam, Lee, Amanda, Watson, Roger
core   +2 more sources