Results 181 to 190 of about 2,067,406 (314)

Research progress on death anxiety in advanced cancer patients

Huli yanjiu, 2023
LIU Hui, LIU Zhili, WU Xiaoying, LI Xiaomin, YING Wenjuan   +4 more
doaj  

Patients' and relatives' perspectives on the quality of end-of-Life care in advanced cancer: From the final months to bereavement. [PDF]

PLoS One
Versluis MAJ, van der Linden YM, van Leeuwen-Snoeks L, van den Beuken-van Everdingen MHJ, Hendriks MP, van den Borne BEEM, Sommeijer D, van Basten JA, van der Padt-Pruijsten A, de Graeff A, Hunting JCB, Kuip EJM, van Lindert ASR, Youssef-El Soud M, Thijs-Visser MF, Vreugdenhil A, van Laarhoven HWM, de Jong WK, Mandigers C, van Zuylen L, Kloover J, Smilde TJ, van de Poll-Franse LV, Raijmakers NJH.   +23 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Safety of intratumoral immunostimulatory LOAd703 gene therapy combined with chemotherapy in patients with advanced cancer. [PDF]

Immunooncol Technol
Hahn A, Irenaeus S, Sandin LC, Wenthe J, Eriksson E, Jarblad JL, Schiza A, Dahlstrand H, Olsson-Strömberg U, Krause J, Sundin A, Loskog A, Ullenhag GJ.   +12 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Progress in Research on Alleviating the Symptoms Associated With Advanced Cancer Using Traditional Chinese Medicine. [PDF]

Pain Res Manag
Jiao C, Zhang T, Yang Y, Zhang R, Liu W, Wang Y, Huang L.   +6 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Validation of the Japanese oral symptom assessment scale (OSAS-J) in patients with advanced cancer. [PDF]

Support Care Cancer
Sena K, Ishiko R, Davies A, Koseki T.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Design, development, and evaluation of an advanced cancer surveillance system. [PDF]

BMC Cancer
Soleimani M, Ghazisaeedi M, Ayyoubzadeh SM, Jalilvand A.   +3 more
europepmc   +1 more source