Results 191 to 200 of about 2,067,406 (314)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

CH Mutations in 16,812 Advanced Cancer Patients-Letter. [PDF]

Clin Cancer Res
Antonarakis ES, Nathanson KL, Reiss KA, Pritchard CC, Berchuck JE, Johnson K, Brown DW, Tukachinsky H.   +7 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Dyadic relationship experience in Chinese patients with advanced cancer and their spouses: A longitudinal qualitative study. [PDF]

Asia Pac J Oncol Nurs
Sun H, Chen X, Huang X, Qin L, Zhu H, Wacharasin C, Hengudomsub P, Zhen Z, Qin Y.   +8 more
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Death Anxiety During the Last Year of Life in Patients With Advanced Cancer: Longitudinal Results From the eQuiPe Study. [PDF]

Psychooncology
Versluis MAJ, de Vries FE, van der Linden YM, Alradhi H, Kool M, Hunting JCB, van Laarhoven HWM, Baars A, de Hosson SM, de Jong WK, Hendriks MP, Everdingen MHJVDB, Smilde TJ, Soud MY, Tilkema-Tiebosch MH, Sommeijer D, de Graeff A, Mandigers C, van Zuylen L, Vreugdenhil A, van der Padt-Pruijsten A, Kuip EJM, van Leeuwen-Snoeks L, van de Poll-Franse LV, Raijmakers NJH.   +24 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Circadian rest-activity rhythm disorders in advanced cancer: assessment, diagnosis and clinical correlates. [PDF]

BMJ Support Palliat Care
Gouldthorpe C, Davies AN.
europepmc   +1 more source

Advances in cancer nanomedicine.

Cancer biology & medicine, 2015
Lin-Tao Cai, Zong-Hai Sheng
openaire   +3 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source