Results 241 to 250 of about 2,075,210 (312)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Effect of Immune Checkpoint Inhibitor Therapy on Biventricular and Biatrial Mechanics in Patients with Advanced Cancer: A Short-Term Follow-Up Study. [PDF]

J Clin Med
Sonaglioni A, Fossile E, Tartaglia N, Nicolosi GL, Lombardo M, Baravelli M, Muti P, Ferrucci PF.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Narrative-based study of spiritual health in advanced cancer patients: insights from Macao's cultural context with broader implications for Asia and beyond. [PDF]

BMC Palliat Care
Lo W, Luo Z.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Modeling metastasis - leveraging novel tools to streamline discovery in advanced cancer.

Dis Model Mech
Eskow NM, Hernando E.
europepmc   +1 more source

"If I am here, it is because the system failed": a critical qualitative study of global commercial clinical trials for advanced cancer in Chile. [PDF]

Global Health
Fernández-González L, Rodin G, Sapunar J, Perez-Brumer A, Birn AE.   +4 more
europepmc   +1 more source

Advanced cancer patients' experience and perception of advance care planning at a university teaching hospital in Northern Tanzania. [PDF]

Palliat Care Soc Pract
Massawe AA, Isack MN, Drury-Smith H, Serventi F, Mmbaga BT, Henke O.   +5 more
europepmc   +1 more source

Broad-Spectrum Antibiotic Use at the End of Life in Patients With Advanced Cancer.

JAMA Netw Open
Kim JH, Yu J, Yoo SH, Sim JA, Keam B, Heo DS.   +5 more
europepmc   +1 more source