Results 81 to 90 of about 2,067,406 (314)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Resectability of the pancreatic adenocarcinoma: A study from Iran

Advanced Biomedical Research, 2014
Background: Definite treatment of pancreatic adenocarcinoma is surgical resection. Absence of early symptoms in most patients leads to late diagnosis and treatment. This study aims to evaluate resectability of the pancreatic adenocarcinoma at the time of
Mahmud Baghbanian, Hasan Salmanroghani, Ali Baghbanian, Mohsen Bakhtpour, Bijan Shabazkhani   +4 more
doaj   +1 more source

Randomised controlled trial of fish oil supplement to treat cancer cachexia [PDF]

, 2015
Patients with advanced cancer often suffer from cachexia, a debilitating and complex extreme weight loss syndrome which is also associated with shorter survival times.
Baughan, C, Dean, Taraneh, Dewey, Ann, Higgins, Bernard Robert, Kilburn, Sally Anne, Stores, Rebecca Jane   +5 more
core   +1 more source

Survival nomograms after curative neoadjuvant chemotherapy and radical surgery for stage IB2-IIIB cervical cancer [PDF]

, 2018
PURPOSE: The purpose of this study was to develop nomograms for predicting the probability of overall survival (OS) and progression-free survival (PFS) in locally advanced cervical cancer treated with neoadjuvant chemotherapy and radical surgery ...
BENEDETTI PANICI, Pierluigi, DE FELICE, Francesca, Di Pinto, Anna, Marchetti, Claudia, Monti, Marco, Musella, Angela, Muzii, Ludovico, Palaia, Innocenza, Romito, Alessia, Tombolini, Vincenzo   +9 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma by Targeting the Epidermal Growth Factor Receptor Combined with Gemcitabine Plus Platinum

Cancer Management and Research, 2020
Chen Chen,1,2,* Xuanye Zhang,2,3,* Yixin Zhou,2,4,* Sha Fu,5 Zuan Lin,2,6 Shaodong Hong,2,3 Li Zhang2,3 1Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China; 2State Key Laboratory
Chen C, Zhang X, Zhou Y, Fu S, Lin Z, Hong S, Zhang L   +6 more
doaj  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Prognostic awareness and prognostic information preferences among advanced cancer patients in Kenya

African Journal of Primary Health Care & Family Medicine
Background: Cancer is the third leading cause of death in Kenya. Yet, little is known about prognostic awareness and preferences for prognostic information.
Hussein Elias, Semra Ozdemir, Joann Bairavi, Emmah Achieng, Eric A. Finkelstein   +4 more
doaj   +1 more source

Starvation tactics using natural compounds for advanced cancers: pharmacodynamics, clinical efficacy, and predictive biomarkers

Cancer Medicine, 2018
The high mortality associated with oncological diseases is mostly due to tumors in advanced stages, and their management is a major challenge in modern oncology.
Khalid El Bairi, Mariam Amrani, Said Afqir   +2 more
doaj   +1 more source

Loss of signal transducer and activator of transcription 1 is associated with prostate cancer recurrence [PDF]

, 2015
STAT1 loss has previously been implicated in cell line studies to modify prostate cancer cell growth and survival, however the clinical significance of this has not previously been established.
Edwards, Joanne, Hatziieremia, Sophia, McCall, Pamela, Mohammed, Zahra, Roseweir, Antonia K., Underwood, Mark A., Willder, Jennifer M.   +6 more
core   +1 more source