Results 51 to 60 of about 201,890 (307)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Challenges of congenital heart disease in grown-up patients

Swiss Medical Weekly, 2017
Nowadays, more than 90% of all children born with congenital heart disease (CHD) reach adult life. Although initially considered to be cured, the majority of them continue to need specialised follow-up because they require re-do interventions or are at
Markus Schwerzmann, Fabienne Schwitz, Corina Thomet, Alexander Kadner, Jean-Pierre Pfammatter, Kerstin Wustmann   +5 more
doaj   +1 more source

Advance Care Planning Conversations in Pediatric Patients with Refractory Oncologic Disease

Children
Advance care planning (ACP) involves longitudinal communication between the patient and physician to explore the patient’s wishes and goals while relaying accurate diagnostic and prognostic information to support informed and shared medical decision ...
Aqsa Khan, Ajay Gupta, Andy Liu, Ali H. Ahmad   +3 more
doaj   +1 more source

Palliative care in advanced Huntington’s disease: a scoping review

BMC Palliative Care, 2023
Background As Huntington’s disease (HD) is a progressive disease for which there is no cure yet, patients in the advanced stage of HD may benefit from palliative care.
Dorine J. Boersema-Wijma, Erik van Duijn, Anne-Wil Heemskerk, Jenny T. van der Steen, Wilco P. Achterberg   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Palliative care for people with advanced liver disease: A feasibility trial of a supportive care liver nurse specialist [PDF]

, 2018
Background:  Liver disease is an increasing cause of death worldwide but palliative care is largely absent for these patients.  Aim:  We conducted a feasibility trial of a complex intervention delivered by a supportive care liver nurse specialist to ...
Byrne, Heidi, Barbara Kimbell, Marilyn Kendall, Brookes-Young, Patricia, Weir, Christopher J, Kendall, Marilyn, Finucane, Anne; id_orcid, O�Carroll, Ronan E, Scott A Murray, Hayes, Peter C, Murray, Scott A, MacGilchrist, Alastair, Weir, Christopher, Heidi Byrne, Brookes Young, Patricia, Finucane, Anne, Young, Patricia Brookes, Christopher J Weir, Peter C Hayes, Anne Finucane, Patricia Brookes Young, Ronan E O’Carroll, Murray, Scott, Kirsty Boyd, Kimbell, Barbara, Weir, Christopher J.; id_orcid, Boyd, Kirsty, Alastair MacGilchrist, Baird, Andrea, Andrea Baird, Hayes, Peter C., O'Carroll, Ronan   +31 more
core   +1 more source

Palliative Approach to Care Education for Multidisciplinary Staff of Long-Term Care Homes: A Pretest Post-Test Study

Gerontology and Geriatric Medicine, 2023
This study used a single-group pre-test and post-test design to evaluate an educational workshop for multidisciplinary staff working in long-term care homes on implementing a palliative approach to care and perceptions about advanced care planning ...
Shirin Vellani NP, PhD, Vanessa Maradiaga Rivas RN, BScN, Maria Nicula MSc, Stephanie Lucchese RN, MN, Julia Kruizinga RN, MScN, Tamara Sussman PhD, Sharon Kaasalainen RN, PhD   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Hilltop Pre-HE Model™: Hospice Eligibility & Advanced Care Planning Fact Sheet

, 2023
The Hilltop Pre-HE Model™—which generates the rankings for the Hospice Eligibility and Advanced Care Planning (Pre-HE) scores—is designed to support proactive advanced care planning discussions by estimating a patient’s risk of eligibility for hospice ...
The Hilltop Institute
core  

Anesthesiological Preoperative Interview with a Palliative Care Patient: A Simulation-Based Experiment Using Standardized Patients

Medicina
Background and Objectives: Anesthesiologists come into contact with patients under palliative care in different clinical settings. They also routinely encounter these patients in their primary field of work, the operating room.
Christoph L. Lassen, Fabian Jaschinsky, Elena Stamouli, Nicole Lindenberg, Christoph H. R. Wiese   +4 more
doaj   +1 more source