Results 171 to 180 of about 4,338,794 (311)

Advanced design of 3D knitted padding for wearable cushioning in knee protector. [PDF]

Sci Rep
Yu A, Zhang Y, Takeuchi S.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Correction: Advanced design and Engi-economical evaluation of an automatic sugarcane seed cutting machine based RGB color sensor. [PDF]

PLoS One
Elwakeel AE, Nasrat LS, Badawy ME, Elzein IM, Mahmoud MM, Kitmo, Hussein MM, Hussein HS, El-Messery TM, Nyambe C, Elsayed S, Ourapi MA.   +11 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Advanced design and fabrication of a medial linkage reciprocal orthosis for patients with spinal cord injury. [PDF]

J Rehabil Assist Technol Eng
Fallah Cham Asmani F, Arazpour M, Khosravi M, Gasavi Nezhad Z, Shafieian M, Adamian A.   +5 more
europepmc   +1 more source

Approaching high-performance potassium-ion batteries via advanced design strategies and engineering. [PDF]

Sci Adv, 2019
Zhang W, Liu Y, Guo Z.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Advanced Design of Soft Robots with Artificial Intelligence. [PDF]

Nanomicro Lett
Cao Y, Xu B, Li B, Fu H.
europepmc   +1 more source

Advanced Design of Minimalistic Dumbbell-shaped Gene Expression Vectors. [PDF]

Bio Protoc, 2017
Jiang X, Patzel V.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source