Results 71 to 80 of about 4,338,794 (311)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Behavioral SciencesDigital sports, also known as online sports, are a new form of sport that users have tried in recent years. Despite the rapid growth of online sports, the factors influencing users’ willingness to sustain their use are currently unknown.
Li Pan +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Steady Flow Force Compensation and Test Research on Electrohydraulic Proportional Relief Valve
IEEE Access, 2019 The pressure control accuracy of electrohydraulic proportional relief valve (EPRV) is affected by steady flow force. Thus, this paper investigates the method of designing a spool groove into the turbine bucket profile to compensate for the steady flow ...
Daohai Qu +4 more
doaj +1 more source
Advanced fibre Bragg grating structures: design and application
, 2004 This thesis presents experimental and computational work on a variety of advanced fibre Bragg grating structures covering long dispersion compensating chirped Bragg gratings, superstructured Bragg gratings for identical multiple channel operation, Bragg ...
Ibsen, Morten
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Desensitized telescope optical design: NSOS-α case study [PDF]
EPJ Web of ConferencesNSOS-α is a 1.5-m aperture, F/1.55, wide field prime focus telescope for the Korea Astronomy & Space Science Institute (KASI) to discover and catalogue near-Earth asteroids, especially Potentially Hazardous Asteroids. Among the different optical designs,
Spanò Paolo +4 more
doaj +1 more source
Advanced tracking systems design and analysis [PDF]
The results of an assessment of several types of high-accuracy tracking systems proposed to track the spacecraft in the National Aeronautics and Space Administration (NASA) Advanced Tracking and Data Relay Satellite System (ATDRSS) are summarized ...
Cunningham, K. +7 more
core +1 more source
Experimental combustor study program [PDF]
, 1980 Advanced combustor concepts are evaluated as a means of accommodating possible future broad specification fuels. The three advanced double annular combustor concepts consisted of (1) a concept employing high pressure drop fuel nozzles for improved ...
Ekstedt, E. E., Kasper, J. M.
core +1 more source