Results 101 to 110 of about 4,649,569 (285)

Some functional differential equations with both retarded and advanced arguments

Journal of Numerical Analysis and Approximation Theory, 2009
In this paper we shall study a functional differential equation of mixed type. This equation is a generalization of some equations from medicine. Related to this equation we study the existence of the solution by contraction's principle and Schauder's ...
Veronica Ana Ilea
doaj   +2 more sources

On advanced functional differential equations with properties \(A\) and \(B\)

, 2001
The authors give new oscillation results for the \(n\)th-order functional-differential equation \[ u^{(n)}(t)=(-1)^k \int_{\tau_0(t)}^{\tau(t)} f(u(s))d_s p(s,t), \] with \(n\geq 2,~ k\in\{1,2\},~ \tau(t)\geq \tau_0(t)\geq t.\) Particular cases of this equation are the following advanced differential equations: \[ u^{(n)}(t)=(-1)^k \sum_{j=1}^m p_j(t ...
Kiguradze, I., Partsvania, N., Stavroulakis, I. P.   +2 more
openaire   +2 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Boundary value problems for the diffusion equation with piecewise continuous time delay

International Journal of Mathematics and Mathematical Sciences, 1997
A study is made of partial differential equations with piecewise constant arguments. Boundary value problems for three types of equations are discussed delayed; alternately of advanced and retarded type; and most importantly, an equation of neutral type (
Joseph Wiener, Lokenath Debnath
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

New Asymptotic and Oscillatory Results for Third-Order Noncanonical Advanced Differential Equations

The aim of this study is to investigate the oscillatory behaviour of a new class of third-order advanced differential equations in their noncanonical form.
Stefano Serra-Capizzano, Asma Althemairi, Ramos, Higinio, Qaraad, Belgees, Althemairi, Asma, Belgees Qaraad, Serra, Stefano, Higinio Ramos, Qaraad, Belgees,, Althemairi, Asma,, Serra, Stefano,, Ramos, Higinio,   +11 more
core   +1 more source

On Asymptotic Behavior of Solutions of Generalized Emden-Fowler Differential Equations with Delay Argument

Abstract and Applied Analysis, 2014
The following differential equation u(n)(t)+p(t)|u(σ(t))|μ(t) sign  u(σ(t))=0 is considered. Here p∈Lloc(R+;R+),  μ∈C(R+;(0,+∞)),  σ∈C(R+;R+),  σ(t)≤t, and limt→+∞⁡σ(t)=+∞.
Alexander Domoshnitsky, Roman Koplatadze
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Higher-order finite-difference methods for partial differential equations [PDF]

, 1997
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis develops two families of numerical methods, based upon rational approximations having distinct real poles, for solving first- and second-order ...
Cheema, Tasleem Akhter
core   +3 more sources