Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Driving Difficulties and Preferences of Advanced Driver Assistance Systems by Older Drivers With Central Vision Loss. [PDF]
Transl Vis Sci Technol, 2023 Xu J, Hutton A, Dougherty BE, Bowers AR.
europepmc +1 more source
Drivers' confidence in advanced drivers assistance systems (ADAS)
Technical SciencesRoad accidents are a serious social problem, both in terms of public health and the costs associated with it, and as individual tragedies. Efforts to reduce the role of human factors in road accidents include partial or full automation of tasks performed by drivers through various types of advanced driver assistance systems.
Przemysław Drożyner +1 more
openaire +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Iraqi Journal for Computer Science and MathematicsDriver behavior has a major role in many of the unpleasant things that happen when driving, such as crashes or accidents, heavy traffic, abrupt braking, and acceleration and deceleration.
ziadoon al-qaysi
doaj +1 more source
Maintaining Safe Driving: Relating Declines In Critical Driving Skills to Advanced Driver Assistance (ADAS) System Technologies [PDF]
, 2023 David W. Eby +4 more
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Anticipatory Shifting - Optimization of a Transmission Control Unit for an Automatic Transmission through Advanced Driver Assistance Systems [PDF]
, 2015 Salim Chaker +3 more
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Optimization of AUTOSAR Communication Stack in the Context of Advanced Driver Assistance Systems. [PDF]
Sensors (Basel), 2021 Bogdan R +6 more
europepmc +1 more source