Results 131 to 140 of about 1,724 (248)

Tirzepatide and SGLT2 Inhibitors for Heart Failure With Preserved Ejection Fraction and Obesity: Entering a New Cardiometabolic Therapeutic Era

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
Tirzepatide and SGLT2 inhibitors act through distinct but complementary mechanisms in obesity‐related HFpEF: tirzepatide targets adiposity, inflammation, and insulin resistance, while SGLT2 inhibitors improve decongestion, myocardial energetics, and cardiac remodeling.
Zakariye Isak Mohamed   +8 more
wiley   +1 more source

Transgenic Conversion of Omega‐6 to Omega‐3 Fatty Acids via fat‐1 Reduces Obesity‐Related Intervertebral Disc Degeneration

open access: yesJOR SPINE, Volume 9, Issue 3, September 2026.
We investigated whether transgenic conversion of omega‐6 to omega‐3 fatty acids mitigates obesity‐associated intervertebral disc (IVD) degeneration. Using fat‐1 mice on a high‐fat diet, we observed that endogenous omega‐3 production prevented diet‐induced disc pathology, metabolic dysfunction, and reduced systemic inflammation, indicating a protective ...
Shirley N. Tang   +8 more
wiley   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

open access: yesMedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen   +3 more
wiley   +1 more source

Whose Digital Future? Civil Society and Alternative Imaginaries in Transnational Digital Governance

open access: yesPolicy &Internet, Volume 18, Issue 3, September 2026.
ABSTRACT This article investigates different visions of digital futures, examining how desired futures are discursively constructed within civil society in transnational digital governance. The analysis builds on discourse theory and a growing body of research on imaginaries in digital governance.
Outi Puukko
wiley   +1 more source

High Awareness, Poor Practice: The Cholera Prevention Knowledge‐Attitude‐Practice Gap in Ada Foah, Ghana—A Cross‐Sectional Study

open access: yesPublic Health Challenges, Volume 5, Issue 3, September 2026.
ABSTRACT Background Cholera persists as a public health threat in Ghana, particularly in coastal communities with inadequate water, sanitation and hygiene (WASH) infrastructure. This study assessed the knowledge, attitudes and practices (KAP) toward cholera among residents of Ada Foah, a high‐risk coastal district in Ghana, to identify gaps and inform ...
Christopher Yaw Dumevi   +11 more
wiley   +1 more source

Innovative Emerging Technologies for Pulse Flour Functionalization: A Comparison With Conventional Thermal and Biological Techniques

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Pulse flours, such as those from peas, beans, and chickpeas, are highly valued for their nutritional density, making them essential for meeting the rising global demand for plant‐based and gluten‐free foods. Despite these nutritional advantages, industrial use is limited by specific sensorial, nutritional, and technological constraints ...
Federico Drudi   +2 more
wiley   +1 more source

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