Results 261 to 270 of about 288,435 (354)

Body composition and checkpoint inhibitor treatment outcomes in advanced melanoma: a multicenter cohort study. [PDF]

J Natl Cancer Inst
Schuiveling M, Ter Maat LS, Van Duin IAJ, Verheijden RJ, Troenokarso MF, Moeskops P, Verhoeff JJC, Elias SG, van Amsterdam WAC, Burgers F, Van den Berkmortel FWPJ, Boers-Sonderen MJ, Boomsma MF, De Groot JW, Haanen JBAG, Hospers GAP, Piersma D, Vreugdenhil G, Westgeest HM, Kapiteijn E, Labots M, Veldhuis WB, Van Diest PJ, De Jong PA, Pluim JPW, Leiner T, Veta M, Suijkerbuijk KPM.   +27 more
europepmc   +1 more source

New developments in the management of advanced melanoma – role of pembrolizumab

, 2015
Giuseppina Improta, Isabella Leone, Marco Donia, Stefania Gieri, Giuseppe Pelosi, Filippo Fraggetta   +5 more
openalex   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Clinical and experimental treatment of advanced melanoma with a focus on immunotherapy. [PDF]

Clin Exp Immunol
Millar L, Di Marco Barros R, Kapiris M, Nikolaou C, Gerlinger M, Wu Y.   +5 more
europepmc   +1 more source

Clinical features and response to systemic therapy in a historical cohort of advanced or unresectable mucosal melanoma

, 2016
Alexander N. Shoushtari, Mark J. Bluth, Debra A. Goldman, Christiana Bitas, Robert A. Lefkowitz, Michael A. Postow, Rodrigo Ramella Munhoz, Gauri Buchar, Robert Harrison Hester, Jacqueline Romero, Laura Fitzpatrick, Martin R. Weiser, Katherine S. Panageas, Jedd D. Wolchok, Paul B. Chapman, Richard D. Carvajal   +15 more
openalex   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

Pembrolizumab and all-trans retinoic acid combination treatment of advanced melanoma: long-term survival update. [PDF]

Ther Adv Med Oncol
Borgers JSW, Medina TM, Robinson WA, Couts KL, Katsnelson EN, Muckle CM, Davilla E, Patel SP, Gao D, Tobin RP, McCarter MD.   +10 more
europepmc   +1 more source

Three Cases of Advanced Melanoma With Severe irAE Colitis With Rapid Tumor Progression Following Infliximab Administration [PDF]

Emi Yamazaki, Taku Fujimura, Yumi Kambayashi, Manami Takahashi, Kenta Oka, Erika Tamabuchi, Yusuke Muto, Akira Hashimoto, Yoshihide Asano   +8 more
openalex   +1 more source

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source

Advanced Melanoma Management: A Case Report of Pembrolizumab Use in a Haemodialysis Patient. [PDF]

Cureus
Teixeira C, Costa R, Silva M, Ribeiro MJ, Sousa I.   +4 more
europepmc   +1 more source