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Systemic Therapies for Advanced Melanoma
Dermatologic Clinics, 2019The incidence of metastatic melanoma continues to increase each decade. Although surgical treatment is often curative for localized stage I and stage II disease, the median survival for patients with distant metastases is less than 1 year. The last 2 decades have witnessed a breakthrough in therapeutic options with the development of immune checkpoint ...
Leonora, Bomar +2 more
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Debulking surgery in advanced melanoma
Expert Review of Anticancer Therapy, 2011In general, patients with stage IV melanoma have poor survival. However, there are subsets of stage IV melanoma patients who are candidates for surgical debulking. There is a growing body of retrospective evidence about clinicians being able to better select patients who may benefit from surgical resection in isolated stage IV disease.
Csaba, Gajdos, Martin D, McCarter
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Management of Locoregionally Advanced Melanoma
Surgical Clinics of North America, 2020Melanoma has a unique propensity for locoregional metastasis secondary to intralymphatic transit not seen in other cutaneous or soft tissue malignancies. Novel intralesional therapies using oncolytic immunotherapy exhibit increasing response rates with observed bystander effect.
David T, Pointer, Jonathan S, Zager
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Surgical Treatment of Advanced Melanoma
Clinics in Plastic Surgery, 2010Primary surgical treatment should be considered for patients with metastatic melanoma. Because of the poor response of melanoma to chemotherapy or radiation therapy, surgery can be the best approach to quickly eliminate detectable disease and return the patient to normal activities.
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Recent advances in melanoma research
Frontiers in Bioscience, 2006At the end of the last decade, sporadic melanomas were still considered a genetic black box. Fortunately, in the last few years the box has been opened bringing to light melanoma-relevant oncogenes, aberrant signal transduction pathways, critical alterations in the melanoma cell cycle that go beyond p16INK4a, and melanoma- microenvironment interactions
Jon A, Reed, Estela E, Medrano
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Melanoma Treatments: Advances and Mechanisms
Journal of Cellular Physiology, 2015Advances in the understanding of the molecular pathogenesis of melanoma and in cancer immunology have led to the rational design and recent clinical implementation of a variety of novel therapies for metastatic melanoma. BRAF and MEK inhibitors that target the MAPK pathway have high rates of clinical response in BRAFâmutant melanoma.
Alexander, Marzuka +3 more
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Dabrafenib Therapy for Advanced Melanoma
Annals of Pharmacotherapy, 2013Objective: To summarize the clinical development of dabrafenib and to highlight the clinically relevant distinct characteristics of dabrafenib in contrast to vemurafenib. Data Source: An English-language literature search of MEDLINE/PubMed (1966-June 2013), using the keywords GSK2118436, dabrafenib, vemurafenib, selective BRAF inhibitor, and advanced ...
Van Anh, Trinh +3 more
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CHEMOTHERAPY OF ADVANCED MALIGNANT-MELANOMA (REVIEW)
Oncology Reports, 1994The role of medical treatment in advanced or metastatic malignant melanoma is still controversial, and there is no standard systemic therapy. Dacarbazine has been the most widely used single drug, despite its response rate range of 10-25%. A number of new drugs, polychemo-therapeutic regimens and combined modalities have been explored.
De Braud F +6 more
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Recent advances in melanoma research
Journal of Dermatological Science, 2001Recent advancement in the research of malignant melanoma is reviewed. Among many gene alterations detected in human melanoma, defect of CDKN2A located at chromosome 9p21 seems to be most important in the earlier developmental phase, though significance of this gene in the evolution of melanoma in situ has not been confirmed yet. Deletions of PTEN/MMAC1
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Future Advances in Melanoma Research
Clinics in Plastic Surgery, 2010The future of melanoma research is promising. Specific mechanisms leading to oncogenic transformation in melanoma development have been identified, and are likely to produce new targets for melanoma therapy. Also, advances in melanoma research will result from melanoma investigators co-opting approaches used to study other malignancies in which ...
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